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Titolo:
Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the partial derivative opioid system in the nucleus accumbens of rat
Autore:
Dauge, V; Samir, A; Cupo, A; Roques, BP;
Indirizzi:
CNRS, UMR 8600,Dept Pharmacochim Mol & Struct, INSERM, U226,UFR Sci Pharmaceut & Biol, F-75270 Paris 06, France CNRS Paris France 06 UFR Sci Pharmaceut & Biol, F-75270 Paris 06, France Hop Bichat, INSERM, U10, Unite Rech Gastroenterol, F-75877 Paris, France Hop Bichat Paris France F-75877 ech Gastroenterol, F-75877 Paris, France CNRS, Inst Pharmacol Mol & Cellulaire, UPR 411, F-06560 Valbonne, France CNRS Valbonne France F-06560 llulaire, UPR 411, F-06560 Valbonne, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 7, volume: 38, anno: 1999,
pagine: 999 - 1007
SICI:
0028-3908(199907)38:7<999:PSOCRB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENKEPHALIN-DEGRADING-ENZYMES; FREELY MOVING RATS; ENDOGENOUS ENKEPHALINS; CHOLECYSTOKININ-OCTAPEPTIDE; LOCOMOTOR-ACTIVITY; GASTRIN RECEPTOR; POTENT; INHIBITOR; DOPAMINE; BRAIN;
Keywords:
CCKB receptor agonists; partial derivative opioid antagonists; mu opioid antagonists; microdialysis; Met-LI CCK-LI release; nucleus accumbens; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Samir, A CNRS, UMR 8600,Dept Pharmacochim Mol & Struct, INSERM, U226,UFR Sci Pharmaceut & Biol, 4 Ave Observ, F-75270 Paris 06, France CNRS 4 Ave Observ Paris France 06 serv, F-75270 Paris 06, France
Citazione:
V. Dauge et al., "Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the partial derivative opioid system in the nucleus accumbens of rat", NEUROPHARM, 38(7), 1999, pp. 999-1007

Abstract

This study analyses the influence of the CCKergic system on the enkepharinergic system in the exploratory behavior of rats, using both behavioral andbiochemical approaches. The results show that the increase of the spontaneous alternation behavior induced by the selective CCRB agonist, BC264 (3 mug/kg) was not suppressed by the opioid antagonists, naloxone (100 mu g/kg), or naltrindole (300 mu g/kg). In contrast, BC264 injected at the same dose induced a hyperlocomotor activity measured in the open-field test, which was antagonized by the selective a opioid antagonist, naltrindole. BC264(3 mu g/kg) significantly increased the extracellular levels of Met-LI in the anterior part of the nucleus accumbens. Furthermore, local injection of naltrindole (0.25 mu g;0.5 mu l) in the anterior nucleus accumbens completely suppressed the hyperlocomotion induced by BC264. The behavioral effects induced by BC264 cannot be explained by its interaction with gastrinic receptors mediating gastric acid release, since BC264 produced a long-lasting increase of gastric acid output from conscious gastric fistula rats only at doses 100 times higher than those inducing behavioral modifications. The hyperlocomotion obtained after stimulation by BC264 of probably peripheral CCRB receptors, indicates that this receptor type could participate in the transmission of information between the peripheral system and some regions of the CNS involved in motivations and emotions. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Documento generato il 16/07/20 alle ore 06:38:32