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Titolo:
Regulation of gonadal and somatotropic axis by chronic intraventricular infusion of insulin-like growth factor 1 antibody at the initiation of puberty in male rats
Autore:
Pazos, F; Sanchez-Franco, F; Balsa, J; Lopez-Fernandez, J; Escalada, J; Cacicedo, L;
Indirizzi:
Hosp Ramon y Cajal, Serv Endocrinol, E-28034 Madrid, Spain Hosp Ramon y Cajal Madrid Spain E-28034 ndocrinol, E-28034 Madrid, Spain Inst Salud Carlos III, Ctr Invest Clin, Madrid, Spain Inst Salud Carlos III Madrid Spain III, Ctr Invest Clin, Madrid, Spain
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 6, volume: 69, anno: 1999,
pagine: 408 - 416
SICI:
0028-3835(199906)69:6<408:ROGASA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; FOLLICLE-STIMULATING-HORMONE; SOMATOSTATIN GENE-EXPRESSION; TREATED MALE-RATS; FACTOR-I; NEGATIVE FEEDBACK; PULSE AMPLITUDE; PITUITARY FOLLISTATIN; DEVELOPMENTAL-CHANGES;
Keywords:
insulin-like growth factors; gonadotropins; growth hormone; somatostatin; puberty; gonads;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Pazos, F Hosp Marques de Valdecilla, Av de Valdecilla S-N, E-34008 Santander, Cantabria, Spain Hosp Marques de Valdecilla Av de Valdecilla S-N Santander Cantabria Spain E-34008
Citazione:
F. Pazos et al., "Regulation of gonadal and somatotropic axis by chronic intraventricular infusion of insulin-like growth factor 1 antibody at the initiation of puberty in male rats", NEUROENDOCR, 69(6), 1999, pp. 408-416

Abstract

There has been increasing experimental evidence to suggest that insulin-like growth factor 1 (IGF-I) may be one of the essential regulators in the reproductive system of the rat. IGF-I is synthesized in the hypothalamus and IGF-I immunoreactivity increases during puberty. Consequently we hypothesized that centrally located IGF-I might contribute to the initiation of puberty. Centrally located IGF-I was immunoneutralized to assess this hypothesis. Male Wistar rats, 28 days old, were infused intracerebroventricularly with specific purified IgGs from rabbit IGF-I antiserum (IGF-I-Ab). The intracerebroventricular administration of IGF-I-Ab resulted in a reduction in testicular weight and consequently in delayed pubertal development. There was also a reduction in serum testosterone, pituitary immunoreactive (IR) luteinizing hormone (LH) and serum IR follicle-stimulating hormone (FSH). The accumulation of beta LH mRNA was not modified, whereas beta FSH mRNA was increased. An increment in the serum growth hormone (GH) levels was also observed. There were no significant alterations in hypothalamic IR growth hormonereleasing factor content, although IR somatostatin (SRIH) content was increased by IGF-I-Ab. The body weight gain remained unaltered. As a whole, ourstudy suggests that centrally located IGF-I influences pubertal development, production and release of gonadotropins and supports the finding that endogenous centrally located IGF-I plays a role at the initiation of puberty in the male rat. It also gives support to the physiological role of centrally located IGF-I in the release of GH mediated by hypothalamic SRIH at the initiation of puberty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:41:32