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Titolo:
Cryptorchidism in mice mutant for Insl3
Autore:
Nef, S; Parada, LF;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 ed Ctr, Ctr Dev Biol, Dallas, TX 75235 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 3, volume: 22, anno: 1999,
pagine: 295 - 299
SICI:
1061-4036(199907)22:3<295:CIMMFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; HORMONAL-CONTROL; CELLS; GUBERNACULUM; EXPRESSION; RECEPTOR; NEURONS; TESTES; MOUSE; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Parada, LF Univ Texas, SW Med Ctr, Ctr Dev Biol, 6000 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 6000 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
S. Nef e L.F. Parada, "Cryptorchidism in mice mutant for Insl3", NAT GENET, 22(3), 1999, pp. 295-299

Abstract

Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births'. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours. Testicular descent from abdomen to scrotum occurs in two distinct phases: the trans-abdominal phase and the inguino-scrotal phase(1-3). Currently, little is known about the factors that regulate the trans-abdominal phase of testicular descent. Leydig insulin-like hormone (Insl3) is a member of the insulin hormone superfamily(4) expressed in the developing testis(5). We show here that mice mutant for Insl(3) are viable, but exhibit bilateral cryptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and infertility. Female homozygotes have impaired fertility associated with deregulation of the oestrus cycle. These findings reveal roles for lnsl(3) in the development of the urogenital tract and in female fertility. lnsl(3) may act as a hormone to regulate the growth and differentiation of the gubernaculum, thereby mediating intra-abdominal testicular descent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:06:56