Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells
Autore:
Urban, BC; Ferguson, DJP; Pain, A; Willcox, N; Plebanski, M; Austyn, JM; Roberts, DJ;
Indirizzi:
John Radcliffe Hosp, Oxford Ctr, Inst Mol Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England John Radcliffe Hosp, Oxford Ctr, Nuffield Dept Pathol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU thol, Oxford OX3 9DU, England John Radcliffe Hosp, Oxford Ctr, Mol Immunol Grp, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Grp, Oxford OX3 9DU, England John Radcliffe Hosp, Oxford Ctr, Nuffield Dept Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Surg, Oxford OX3 9DU, England John Radcliffe Hosp, Oxford Ctr, Natl Blood Serv, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Serv, Oxford OX3 9DU, England
Titolo Testata:
NATURE
fascicolo: 6739, volume: 400, anno: 1999,
pagine: 73 - 77
SICI:
0028-0836(19990701)400:6739<73:PFEMTM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALARIA-PARASITIZED ERYTHROCYTES; ANTIGENIC VARIATION; RECEPTOR; CYTOADHERENCE; SEQUESTRATION; ASSOCIATION; PHENOTYPES; IMMUNITY; ADHESION; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, DJ John Radcliffe Hosp, Oxford Ctr, Inst Mol Med, Oxford OX3 9DU,England John Radcliffe Hosp Oxford England OX3 9DU OX3 9DU, England
Citazione:
B.C. Urban et al., "Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells", NATURE, 400(6739), 1999, pp. 73-77

Abstract

The malaria parasite Plasmodium falciparum is one of the most successful human pathogens. Specific virulence factors remain poorly defined, although the adhesion of infected erythrocytes to the venular endothelium has been associated with some of the syndromes of severe disease(1). Immune responsescannot prevent the development of symptomatic infections throughout life, and clinical immunity to the disease develops only slowly during childhood. An understanding of the obstacles to the development of protective immunity is crucial for developing rational approaches to prevent the disease. Here we show that intact malaria-infected erythrocytes adhere to dendritic cells, inhibit the maturation of dendritic cells and subsequently reduce theircapacity to stimulate T cells. These data demonstrate both a novel mechanism by which malaria parasites induce immune dysregulation and a functional role beyond endothelial adhesion for the adhesive phenotypes expressed at the surface of infected erythrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:47:57