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Titolo:
The Women's Ischemia Syndrome Evaluation (WISE) study: Protocol design, methodology and feasibility report
Autore:
Merz, CNB; Kelsey, SF; Pepine, CJ; Reichek, N; Reis, SE; Rogers, WJ; Sharaf, BL; Sopko, G;
Indirizzi:
Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, Los Angeles, CA USA Cedars Sinai Med Ctr Los Angeles CA USA Div Cardiol, Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 idemiol, Pittsburgh, PA 15260 USA Univ Florida, Dept Med, Div Cardiol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Cardiol, Gainesville, FL 32611 USA Allegheny Gen Hosp, Div Cardiol, Dept Med, MCP Hahnemann Sch Med, Pittsburgh, PA 15212 USA Allegheny Gen Hosp Pittsburgh PA USA 15212 Med, Pittsburgh, PA 15212 USA Univ Pittsburgh, Div Cardiol, Dept Med, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ept Med, Pittsburgh, PA 15260 USA Univ Alabama, Dept Med, Div Cardiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 iv Cardiol, Birmingham, AL 35294 USA Rhode Isl Hosp, Providence, RI 02903 USA Rhode Isl Hosp Providence RI USA02903 Isl Hosp, Providence, RI 02903 USA NHLBI, Div Heart & Vasc Dis, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 Heart & Vasc Dis, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 6, volume: 33, anno: 1999,
pagine: 1453 - 1461
SICI:
0735-1097(199905)33:6<1453:TWISE(>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; HEART-DISEASE; POSTMENOPAUSAL WOMEN; BYPASS-SURGERY; N-13 AMMONIA; RISK-FACTORS; BLOOD-FLOW; PILOT ACIP; EXERCISE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Merz, CNB Univ Pittsburgh, Grad Sch Publ Hlth, Wise Coordinating Ctr, 127 Parran Hall,130 DeSoto St, Pittsburgh, PA 15261 USA Univ Pittsburgh 127 Parran Hall,130 DeSoto St Pittsburgh PA USA 15261
Citazione:
C.N.B. Merz et al., "The Women's Ischemia Syndrome Evaluation (WISE) study: Protocol design, methodology and feasibility report", J AM COL C, 33(6), 1999, pp. 1453-1461

Abstract

OBJECTIVESThe Women's Ischemia Syndrome Evaluation (WISE) is a National Heart, Lung and Blood Institute-sponsored four-center study designed to: 1) optimize symptom evaluation and diagnostic testing for ischemic heart disease; 2) explore mechanisms for symptoms and myocardial ischemia in the absence of epicardial corollary artery stenoses, and 3) evaluate the influence of reproductive hormones on symptoms and diagnostic test response. BACKGROUNDAccurate diagnosis of ischemic heart disease in women is a major challengeto physicians, and the role reproductive hormones play in this diagnostic uncertainty is unexplored. Moreover, the significance and pathophysiology of ischemia in the absence of significant epicardial coronary stenoses is unknown. METHODSThe WISE common core data include demographic and clinical data, symptom and psychosocial variables, coronary angiographic and ventriculographic data, brachial artery reactivity testing, resting/ambulatory electrocardiographic monitoring and a variety of blood determinations Site-specific complementary methods include physiologic and functional cardiovascular assessments of myocardial perfusion and metabolism, ventriculography, endothelial vascular function and coronary angiography. Women are followed for at least 1 year to assess clinical events and symptom status. RESULTSIn Phase I (1996-1997), a pilot phase, 256 women were studied. These data indicate that the WISE protocol is safe and feasible for identifying symptomatic women with and without significant epicardial coronary artery stenoses. CONCLUSIONSThe WISE study will define contemporary diagnostic testing to evaluate women with suspected ischemic heart disease. Phase II (1997-1999) is ongoing and will study an additional 680 women, for a total WISE enrollment of 936 women. Phase III (2000) will include patient follow-up, data analysis and a National Institutes of Health WISE workshop. (C) 1999 by the American College of Cardiology.

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Documento generato il 26/01/20 alle ore 22:40:14