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Titolo:
Identification of genetic aberrations in cell lines from oral squamous cell carcinomas by comparative genomic hybridization
Autore:
Okafuji, M; Ita, M; Hayatsu, Y; Shinozaki, F; Oga, A; Sasaki, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Oral & Maxillofacial Surg, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
JOURNAL OF ORAL PATHOLOGY & MEDICINE
fascicolo: 6, volume: 28, anno: 1999,
pagine: 241 - 245
SICI:
0904-2512(199907)28:6<241:IOGAIC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAND CANCER CELL; SOLID TUMORS; NECK-CANCER; HEAD; CHROMOSOME-4; VESNARINONE; INDUCTION; TSC-22; KINASE;
Keywords:
CGH; chromosome; DNA; genetic aberration; oral squamous cell carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Okafuji, M Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 uchi 7558505, Japan
Citazione:
M. Okafuji et al., "Identification of genetic aberrations in cell lines from oral squamous cell carcinomas by comparative genomic hybridization", J ORAL PATH, 28(6), 1999, pp. 241-245

Abstract

We detected genetic alterations in 14 cell lines established from 14 humanoral squamous cell carcinomas (OSCCs) using comparative genomic hybridization (CGH), which allows a comprehensive analysis of chromosomal imbalances and identification of nonrandom genetic aberrations specific to OSCCs. All cell lines showed gains and losses of DNA copy number. DNA losses were detected for chromosomes 18q (10/14) and 4q (9/14) with minimal overlapping regions of 18q12-32 and 4q31-qter, respectively. In contrast, the common sitesfor increased copy number were chromosomes 5p (12/14), 8q23-ter (11/14), 20p (8/14), 20q (8/14), and 3q25-ter (7/14). These results suggest that losses of 18q12-22 and 4q31-ter and gains of 5p and 8q23-ter play important roles in the development and/or progression of OSCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:17:36