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Titolo:
Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome
Autore:
Lo Muziol, L; Staibano, S; Pannone, G; Bucci, P; Nocini, PF; Bucci, E; De Rosa, G;
Indirizzi:
Univ Naples Federico II, Fac Med, Sch Dent, Dept Oral Med & Pathol, Naples, Italy Univ Naples Federico II Naples Italy t Oral Med & Pathol, Naples, Italy Univ Naples Federico II, Fac Med, Dept Biomorphol & Funct Sci, Pathol Unit, Naples, Italy Univ Naples Federico II Naples Italy ct Sci, Pathol Unit, Naples, Italy Univ Verona, Fac Med, Div Oral & Maxillofacial Surg, I-37100 Verona, ItalyUniv Verona Verona Italy I-37100 xillofacial Surg, I-37100 Verona, Italy
Titolo Testata:
JOURNAL OF DENTAL RESEARCH
fascicolo: 7, volume: 78, anno: 1999,
pagine: 1345 - 1353
SICI:
0022-0345(199907)78:7<1345:EOCCAA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR ANTIGEN PCNA; DROSOPHILA PATCHED GENE; NEVUS SYNDROME; HUMAN HOMOLOG; MANDIBULAR KERATOCYST; BCL-2 EXPRESSION; GORLIN-SYNDROME; BREAST-CANCER; P53; TUMOR;
Keywords:
p53; PCNA; bcl-2; bcl-1; AgNOR; immunocytochemistry; mutation; nevoid basal cell carcinoma syndrome; odontogenic cysts; odontogenic keratocysts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Lo Muziol, L Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 FoggiaItaly I-71100 , I-71100 Foggia, Italy
Citazione:
L. Lo Muziol et al., "Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome", J DENT RES, 78(7), 1999, pp. 1345-1353

Abstract

Odontogenic keratocysts are occasionally (4-5%) associated with the nevoidbasal cell carcinoma syndrome, a pleiotropic, autosomal disorder presenting a spectrum of developmental abnormalities and a predisposition for the development of different neoplasms. The aim of this study was to establish whether keratocysts showing clinically aggressive behavior associated with nevoid basal cell carcinoma syndrome reflect differences in cellular proliferation rate and/or in the expression of oncoproteins and tumor suppressor genes. For this reason, formalin-fixed paraffin-embedded sections of odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome (16 cases) and sporadic odontogenic keratocysts (16 cases) were compared for expression of proliferating cell nuclear antigen (PCNA) and p53, bcl-2, andbcl-1 (cyclin D1) once-proteins. Most of the epithelial lining of odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome showed nuclear immunopositivity for p53 protein and overexpression of cyclin D1 with various degrees of staining intensity. All sporadic odontogenic keratocysts were negative for p53 and cyclin D1. The expressions of bcl-2 oncoprotein were found to be substantially similar between the two groups of lesions, with a cytoplasmic immunopositivity localized only in the resting reserve basal layer of the epithelium. PCNA expression showed no statistically significant difference between the two groups of lesions. In conclusion, the finding of cyclin D1 and p53 overexpression in odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome could be considered a hallmark of a mutated cellular phenotype, thus leading to the hypothesis that their aggressive clinical behavior could be due to a dysregulation of the expression of cyclin D1 and p53 proteins, involved in a check-point control of cellular proliferation.

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Documento generato il 12/07/20 alle ore 03:23:02