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Titolo:
Positional changes of the frontoparietal ossification centers in perinatalcraniosynostotic rabbits
Autore:
Dechant, JJ; Mooney, MP; Cooper, GM; Smith, TD; Burrows, AM; Losken, HW; Mathijssen, IMJ; Siegel, MI;
Indirizzi:
Univ Pittsburgh, Sch Nursing, Dept Hlth Promot & Dev, Pittsburgh, PA 15261USA Univ Pittsburgh Pittsburgh PA USA 15261 ot & Dev, Pittsburgh, PA 15261USA Univ Pittsburgh, Dept Anthropol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thropol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Plast & Reconstruct Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ct Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thodont, Pittsburgh, PA 15261 USA Univ Pittsburgh, Cleft Palate Craniofacial Ctr, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ial Ctr, Pittsburgh, PA 15261 USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ct Surg, Pittsburgh, PA 15261 USA Slippery Rock Univ, Dept Phys Therapy, Slippery Rock, PA 16057 USA Slippery Rock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA Childrens Hosp, Pittsburgh, PA 15213 USA Childrens Hosp Pittsburgh PA USA15213 ens Hosp, Pittsburgh, PA 15213 USA Erasmus Univ, Inst Plast Surg, Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands t Plast Surg, Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 19, anno: 1999,
pagine: 64 - 74
SICI:
0270-4145(199904/06)19:2<64:PCOTFO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; CRANIAL SUTURE FUSION; TGF-BETA SUPERFAMILY; DURA-MATER; IN-VITRO; TRANSFORMING GROWTH-FACTOR-BETA-1; SYNOSTOTIC PROGRESSION; OSSEOUS OBLITERATION; INTRACRANIAL VOLUME; TISSUE INTERACTIONS;
Keywords:
isolated synostosis; coronal suture; bony tuber; pathogenesis; nonsyndromic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Dechant, JJ Univ Pittsburgh, Sch Nursing, Dept Hlth Promot & Dev, 463 Victoria Bldg, Pittsburgh, PA 15261 USA Univ Pittsburgh 463 Victoria Bldg Pittsburgh PA USA 15261 USA
Citazione:
J.J. Dechant et al., "Positional changes of the frontoparietal ossification centers in perinatalcraniosynostotic rabbits", J CRAN GENE, 19(2), 1999, pp. 64-74

Abstract

It has been suggested that craniosynostosis is caused by abnormally located ossification centers (i.e., bony tubers) in the developing skull prior tosuture formation [Mathijssen et al., 1996, 1997]. The present study was designed to test this hypothesis in a rabbit model of human familial, nonsyndromic coronal suture (CS) synostosis. Calvariae were taken from 99 New Zealand White rabbit perinates (55 normal controls, 15 with delayed-onset CS synostosis, and 29 with bilateral or unilateral CS synostosis), ranging in age from 23 to 34 days postconception (synostosis occurs at approximately 13 days in this model). Frontoparietal, interfrontal, and interparietal ossification center distances were obtained using a Wild microscope with camera lucida attachment and a 2-D computer digitization technique. Linear regression analysis was used to compare age-related changes in the perinatal ossification centers among groups. Results revealed that frontoparietal ossification center regression line slopes had similar stare points (24-day intercepts) with significantly (P < 0.05) diverging slopes over lime. Normal and delayed-onset ossification center distance increased more rapidly than in synostosed perinates. No significant (P > 0.05) differences were noted in regression line slopes among groups for interparietal or interfrontal ossification center distances. Results demonstrated that, in synostosed perinates, frontoparietal ossification center location was similar to normals around the time of synostosis and became displaced later. These findings suggest that ossification center (i.e.,bony tuber) displacement seen in infants with craniosynostosis is probably a secondary and compensatory, postsynostotic change and not a primary causal factor of synostosis in this rabbit model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:02:55