Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tracing craniosynostosis to its developmental stage through bone center displacement
Autore:
Mathijssen, IMJ; van Splunder, J; Vermeij-Keers, C; Pieterman, H; de Jong, THR; Mooney, MP; Vaandrager, JM;
Indirizzi:
Erasmus Med Ctr, Inst Plast Surg, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Plast & Reconstruct Surg, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Radiol, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Neurosurg, NL-3000 DR Rotterdam, Netherlands ErasmusMed Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Histol, Pittsburgh, PA 15260 USA
Titolo Testata:
JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 19, anno: 1999,
pagine: 57 - 63
SICI:
0270-4145(199904/06)19:2<57:TCTIDS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAETHRE-CHOTZEN-SYNDROME; CROUZON SYNDROME; POINT MUTATION; FGFR2; TWIST; GENE; PATHOGENESIS; PFEIFFER; APERT;
Keywords:
embryogenesis; pathogenesis; cranium; birth defect; craniofacial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Mathijssen, IMJ Erasmus Med Ctr, Inst Plast Surg, Room Ee 1257,POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Room Ee 1257,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
I.M.J. Mathijssen et al., "Tracing craniosynostosis to its developmental stage through bone center displacement", J CRAN GENE, 19(2), 1999, pp. 57-63

Abstract

In metopic and coronal suture synostosis, the involved bone centers are abnormally situated just next to the affected suture. Bone centers are the starting point of ossification during embryogenesis from which bone growth spreads radially. In this paper, we describe a similar observation for sagittal suture synostosis, with both parietal bone centers located almost completely cranially. The (reduced) distance between the bone centers of a synostotic suture reflects the time during embryogenesis at which fusion took place. We suggest that in craniosynostosis the bone centers arise in their normal position, and initial outgrowth is undisturbed until the bone fronts meet. It is during this developmental stage that fusion occurs instead of suture formation. Due to the fusion, growth can only occur at the free bony rims from then on. The bone centers remain located at a fixed distance from one another in the middle of the fused bones, becoming relatively more displaced with time. This implies that the distance between the involved bone centers directly indicates the developmental period during which sutural growth was arrested. The same phenomenon of bone center displacement is found in types of craniosynostosis with and without fibroblast growth factor receptor (FGFR) or TWIST gene mutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:05:14