Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The autonomic control of the transmural dispersion of ventricular repolarization in anesthetized dogs
Autore:
Takei, M; Sasaki, Y; Yonezawa, T; Lakhe, M; Aruga, M; Kiyosawa, K;
Indirizzi:
Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 7, volume: 10, anno: 1999,
pagine: 981 - 989
SICI:
1045-3873(199907)10:7<981:TACOTT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; LONG-QT SYNDROME; SYMPATHETIC-PARASYMPATHETIC INTERACTIONS; VAGUS NERVE-STIMULATION; M-CELLS; CANINE VENTRICLE; HEART-RATE; TRIGGERED ACTIVITY; CONSCIOUS DOGS; VAGAL NERVES;
Keywords:
autonomic nervous system; cardiac arrhythmias; cardiac electrophysiology; endocardium; epicardium; M cells; parasympathetic nerves; sympathetic nerves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Takei, M Shinshu Univ, Sch Med, Dept Internal Med 2, 3-1-1 Asahi, Matsumoto, Nagano3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 21, Japan
Citazione:
M. Takei et al., "The autonomic control of the transmural dispersion of ventricular repolarization in anesthetized dogs", J CARD ELEC, 10(7), 1999, pp. 981-989

Abstract

Introduction: The initiation of ventricular arrhythmias is in part associated with autonomic nervous tone. We investigated the effects of Sympatheticand parasympathetic stimulation on the monophasic action potentials (MAPs)of the epicardium (EPI), mid-myocardial (M) region, and endocardium (Endo)in vivo. Methods and Results: In 12 mongrel open chest anesthetized dogs, both sides of the cervical vagus nerves and stellate ganglia were crushed with a tight ligature, Right atrial pacing at 600 msec cycle length was begun after the sinus nodal area had been crushed. MAPs from the M region were measured by two needle electrodes that were supported by a W-shaped plastic frame. The epicardial, M region, and endocardial MAP durations at 90% repolarization (MAPD(90)) were 287 +/- 7, 315 +/- 7, and 290 +/- 8 msec, respectively, The MAPD(90) from M cells was longer than that from Epi or Endo, Sympatheticstimulation shortened MAPD(90) more in the M region (53 +/- 4 msec) than that in the Epi (27 +/- 3 msec) or Endo (26 +/- 4 msec), The transmural dispersion of repolarization during sympathetic stimulation was shorter than that of the control. Parasympathetic stimulation did not significantly affectany of the MAPD(90) values, Simultaneous sympathetic and parasympathetic stimulation produced changes not significantly to those produced by sympathetic stimulation alone,Conclusion: Our results suggest that sympathetic activity can reduce transmural dispersion of repolarization under autonomic control in the canine heart under baseline conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 11:59:42