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Titolo:
Arcadlin is a neural activity-regulated cadherin involved in long term potentiation
Autore:
Yamagata, K; Andreasson, KI; Sugiura, H; Maru, E; Dominique, M; Irie, Y; Miki, N; Hayashi, Y; Yoshioka, M; Kaneko, K; Kato, H; Worley, PF;
Indirizzi:
Tokyo Metropolitan Inst Neurosci, Dept Mol Neurobiol, Fuchu, Tokyo 183, Japan Tokyo Metropolitan Inst Neurosci Fuchu Tokyo Japan 183 , Tokyo 183, Japan Johns Hopkins Univ, Sch Med, Dept Neurol & Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Nippon Med Univ, Sch Med, Dept Physiol 2, Tokyo 113, Japan Nippon Med Univ Tokyo Japan 113 ch Med, Dept Physiol 2, Tokyo 113, Japan Ctr Med Univ Geneva, Dept Pharmacol, CH-1211 Geneva 4, Switzerland Ctr MedUniv Geneva Geneva Switzerland 4 , CH-1211 Geneva 4, Switzerland Osaka Univ, Sch Med, Dept Pharmacol 1, Suita, Osaka 565, Japan Osaka UnivSuita Osaka Japan 565 ept Pharmacol 1, Suita, Osaka 565, Japan Nagano Nursing Univ, Komagane 39941, Japan Nagano Nursing Univ Komagane Japan 39941 ing Univ, Komagane 39941, Japan Yamagata Univ, Sch Med, Dept Physiol 2, Yamagata 99023, Japan Yamagata Univ Yamagata Japan 99023 Dept Physiol 2, Yamagata 99023, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 27, volume: 274, anno: 1999,
pagine: 19473 - 19479
SICI:
0021-9258(19990702)274:27<19473:AIANAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINGER TRANSCRIPTION FACTOR; CELL-CELL INTERACTIONS; FACTOR MESSENGER-RNAS; SYNAPTIC PLASTICITY; ADHESION MOLECULE; BRAIN NEURONS; GROWTH-FACTOR; RAT-BRAIN; PROTEIN; NCAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yamagata, K Tokyo Metropolitan Inst Neurosci, Dept Mol Neurobiol, 2-6 Musashidai, Fuchu, Tokyo 183, Japan Tokyo Metropolitan Inst Neurosci 2-6 Musashidai Fuchu Tokyo Japan 183
Citazione:
K. Yamagata et al., "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation", J BIOL CHEM, 274(27), 1999, pp. 19473-19479

Abstract

Neural activity results in long term changes that underlie synaptic plasticity. To examine the molecular basis of activity-dependent plasticity, we have used differential cloning techniques to identify genes that are rapidlyinduced in brain neurons by synaptic activity. Here, we identify a novel cadherin molecule Arcadlin (activity-regulated cadherin-like protein), arcadlin mRNA is rapidly and transiently induced in hippocampal granule cells byseizures and by N-methyl-D-aspartate-dependent synaptic activity in long term potentiation. The extracellular domain of Arcadlin is most homologous to protocadherin-8; however, the cytoplasmic region is distinct from that ofany cadherin family member. Arcadlin protein is expressed at the synapses and shows a hemophilic binding activity in a Ca2+-dependent manner, Furthermore, application of Arcadlin antibody reduces excitatory postsynaptic potential amplitude and blocks long term potentiation in hippocampal slices. Its close homology with cadherins, its rapid inducibility by neural activity,and its involvement in synaptic transmission suggest that Arcadlin may play an important role in activity-induced synaptic reorganization underlying long term memory.

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Documento generato il 07/08/20 alle ore 06:58:19