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Titolo:
A null mutation in murine CD36 reveals an important role in fatty acid andlipoprotein metabolism
Autore:
Febbraio, M; Abumrad, NA; Hajjar, DP; Sharma, K; Cheng, WL; Pearce, SFA; Silverstein, RL;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Med, Div Hematol Oncol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Hematol Oncol, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Ctr Vasc Biol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Ctr Vasc Biol, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 l, Dept Pathol, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA CornellUniv New York NY USA 10021 , Dept Biochem, New York, NY 10021 USA SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 phys, Stony Brook, NY 11794 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 27, volume: 274, anno: 1999,
pagine: 19055 - 19062
SICI:
0021-9258(19990702)274:27<19055:ANMIMC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MACROPHAGE SCAVENGER RECEPTORS; ADIPOCYTE MEMBRANE-PROTEIN; PPAR-GAMMA ACTIVATORS; SR-BI; PREADIPOCYTE DIFFERENTIATION; CHOLESTEROL DEPOSITION; APOPTOTIC THYMOCYTES; EXPRESSION CLONING; BINDING-PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Febbraio, M Cornell Univ, Weill Med Coll, Dept Med, Div Hematol Oncol, 1300 York Ave, New York, NY 10021 USA Cornell Univ 1300 York Ave New York NY USA 10021 NY 10021 USA
Citazione:
M. Febbraio et al., "A null mutation in murine CD36 reveals an important role in fatty acid andlipoprotein metabolism", J BIOL CHEM, 274(27), 1999, pp. 19055-19062

Abstract

A null mutation in the scavenger receptor gene CD36 was created in mice bytargeted homologous recombination. These mice produced no detectable CD36 protein, were viable, and bred normally. A significant decrease in binding and uptake of oxidized low density lipoprotein was observed in peritoneal macrophages of null mice as compared with those from control mice. CD36 nullanimals had a significant increase in fasting levels of cholesterol, nonesterified free fatty acids, and triacylglycerol. The increase in cholesterolwas mainly within the high density lipoprotein fraction, while the increase in triacylglycerol was within the very low density lipoprotein fraction. Null animals had lower fasting serum glucose levels when compared with wildtype controls. Uptake of H-3-labeled oleate was significantly reduced in adipocytes from null mice. However, the decrease was limited to the low ratios of fatty acid:bovine serum albumin, suggesting that CD36 was necessary for the high affinity component of the uptake process. The data provide evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 16:35:15