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Titolo:
Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice
Autore:
Sakiyama, T; Ikuta, K; Nisitani, S; Takatsu, K; Honjo, T;
Indirizzi:
Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Univ Tokyo, Inst Med Sci, Dept Immunol, Tokyo 108, Japan Univ Tokyo Tokyo Japan 108 Inst Med Sci, Dept Immunol, Tokyo 108, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 6, volume: 11, anno: 1999,
pagine: 995 - 1000
SICI:
0953-8178(199906)11:6<995:ROIFIO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LY-1 B-CELLS; B-1 CELLS; INTERLEUKIN-5;
Keywords:
autoimmune hemolytic anemia; IL-5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Honjo, T Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
T. Sakiyama et al., "Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice", INT IMMUNOL, 11(6), 1999, pp. 995-1000

Abstract

IL-5, IL-10 and lipopolysaccharide (LPS) are known to activate B-1 cells in vivo in normal mice and anti-red blood cell autoantibody transgenic mice (HL mice). To assess the exact role of IL-5 in proliferation and activationof peritoneal B-1 cells, we analyzed IL-5 receptor a chain-deficient HL (IL-5Ra(-/-) x HL) mice generated by the cross between IL-5R alpha(-/-) and HL mice. In IL-5R alpha(-/-) x HL mice, Ig-producing B-1 cells in the peritoneal cavity were negligible, although the total number of B-1 cells in the peritoneal cavity were as many as 30% of that in HL mice. Moreover, LPS- orIL-10-induced differentiation of B-l cells into antibody-producing cells was severely impaired in IL-5R alpha(-/-) x HL mice. We also used in vivo 5-bromo-2'-deoxyuridine labeling to estimate the proliferation of B-1 cells in IL-5R alpha(-/-) mice. The absence of IL-5R alpha did not affect spontaneous proliferation of peritoneal B-1 cells. However, induced proliferation of peritoreal B-1 cells by oral administration of LPS was markedly impaired in IL-5R alpha(-/-) mice. These results suggest that IL-5 is required for activation-associated proliferation of B-1 cells but not for their spontaneous proliferation and support the idea that IL-5 plays an important role on the induction of autoantibody production from B-l cells.

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Documento generato il 29/01/20 alle ore 19:11:28