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Titolo:
Relationship between insulin and blood pressure in Japanese obese subjects
Autore:
Oshida, Y; Yamanouchi, K; Ohsawa, I; Usui, K; Sato, J; Kajita, M; Sato, Y;
Indirizzi:
Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Chikusa Ku, Nagoya, Aichi4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 sa Ku, Nagoya, Aichi4648601, Japan
Titolo Testata:
INTERNAL MEDICINE
fascicolo: 6, volume: 38, anno: 1999,
pagine: 467 - 471
SICI:
0918-2918(199906)38:6<467:RBIABP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESSENTIAL-HYPERTENSION; RESISTANCE; METABOLISM; CLEARANCE; WEIGHT;
Keywords:
obesity; insulin resistance; younger and older subjects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Oshida, Y Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan Nagoya Univ Furo Cho Nagoya Aichi Japan4648601 i 4648601, Japan
Citazione:
Y. Oshida et al., "Relationship between insulin and blood pressure in Japanese obese subjects", INTERN MED, 38(6), 1999, pp. 467-471

Abstract

Object: The association of obesity and hypertension is well recognized. However, the nature of the relationship between increased body weight and blood pressure (BP) elevation has remained obscure. Patients and Methods: We evaluated BP, insulin sensitivity, insulin clearance and fasting plasma insulin concentration in 19 younger (over 40 years) and in 15 older (more than 40 years) obese subjects to determine the relationships between BP and other factors. Insulin sensitivity and clearance were determined with the euglycemic clamp technique, Results: BP was not associated with insulin sensitivity although most of the subjects showed insulin resistance. In the youngerobese group, a positive correlation between diastolic BP and body mass index (kg/m(2)) was found (r=0.740; p=0.013). In the older obese group, systolic and diastolic BP were correlated with fasting plasma insulin levels (r=0.705; p=0.003; r=0.574; p=0.025, respectively), and systolic BP was inversely correlated with insulin clearance (r=-0.715, p=0.003). Conclusion: Theseresults suggest that insulin is an important factor in BP elevation in older obese subjects, but not in younger obese subjects.

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Documento generato il 15/07/20 alle ore 15:04:03