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Titolo:
Inflammatory alterations in mesenteric adipose tissue in Crohn's disease
Autore:
Desreumaux, P; Ernst, O; Geboes, K; Gambiez, L; Berrebi, D; Muller-Alouf, H; Hafraoui, S; Emilie, D; Ectors, N; Peuchmaur, M; Cortot, A; Capron, M; Auwerx, J; Colombel, JF;
Indirizzi:
CHU Lille, Hop Huriez, Clin Malad Appareil Digest & Nutr,CRI 4U004B, Lab Rech Maladies Inflammat Intestinales, F-59037 Lille, France CHU Lille Lille France F-59037 ammat Intestinales, F-59037 Lille, France Inst Pasteur, INSERM, U167, Ctr Immunol & Biol Parasitaire, F-59019 Lille,France Inst Pasteur Lille France F-59019 Biol Parasitaire, F-59019 Lille,France CHU Lille, Hop Huriez, Serv Radiol, F-59037 Lille, France CHU Lille Lille France F-59037 uriez, Serv Radiol, F-59037 Lille, France Katholieke Univ Leuven, Dept Pathol, Leuven, Belgium Katholieke Univ Leuven Leuven Belgium ven, Dept Pathol, Leuven, Belgium Hop Robert Debre, Serv Anat & Cytol Pathol, F-75019 Paris, France Hop Robert Debre Paris France F-75019 ytol Pathol, F-75019 Paris, France Inst Paris Sud Cytokines, INSERM, U131, Clamart, France Inst Paris Sud Cytokines Clamart France , INSERM, U131, Clamart, France Inst Pasteur, INSERM, U325, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 1, volume: 117, anno: 1999,
pagine: 73 - 81
SICI:
0016-5085(199907)117:1<73:IAIMAT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ACTIVATED RECEPTOR-GAMMA; CD4(+) T-CELLS; FACTOR-ALPHA; GENE-EXPRESSION; BOWEL-DISEASE; TRANSGENIC MICE; PPAR-GAMMA; TNF-ALPHA; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Colombel, JF CHU Lille, Hop Huriez, Clin Malad Appareil Digest & Nutr,CRI 4U004B, Lab Rech Maladies Inflammat Intestinales, F-59037 Lille, France CHULille Lille France F-59037 nales, F-59037 Lille, France
Citazione:
P. Desreumaux et al., "Inflammatory alterations in mesenteric adipose tissue in Crohn's disease", GASTROENTY, 117(1), 1999, pp. 73-81

Abstract

Background & Aims: Abnormalities of fat in the mesentery including adiposetissue hypertrophy and fat wrapping have been long recognized on surgical specimens as characteristic features of Crohn's disease. However, the importance, origin, and significance of the mesenteric fat hypertrophy in this chronic inflammatory disease am unknown. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a crucial factor involved in the homeostasis of adipose tissue, a major source of biologically active mediators. Methods: Intraabdominal fat accumulation was quantified using a magnetic resonanceimaging method in patients with Crohn's disease and controls. PPAR gamma and inflammatory cytokines synthesized by mesenteric adipose tissues were assessed by quantitative polymerase chain reaction, in situ hybridization, and immunohistochemistry. Results: In vivo, patients with Crohn's disease have an important accumulation of intra-abdominal fat. This mesenteric obesity, present from the onset of the disease, is associated with overexpression of PPAR gamma and tumor necrosis factor (TNF)-alpha, synthesized, at least in part, by adipocytes. Conclusions: These results suggest that confined increased PPAR gamma mesenteric concentrations could lead to the mesenteric fat hypertrophy, which could actively participate through the synthesis of TNF-alpha in the inflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:33:17