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Titolo:
Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age
Autore:
Sorensen, N; Murata, K; Budtz-Jorgensen, E; Weihe, P; Grandjean, P;
Indirizzi:
Faroese Hosp Syst, Dept Occupat & Publ Hlth, Torshavn, Faroe Islands, Denmark Faroese Hosp Syst Torshavn Faroe Islands Denmark Faroe Islands, Denmark Univ Tokyo, Fac Med, Dept Publ Hlth, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 yo, Fac Med, Dept Publ Hlth, Tokyo 113, Japan Univ Copenhagen, Panum Inst, Dept Biostat, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark Odense Univ, Inst Community Hlth, Odense, Denmark Odense Univ Odense Denmark e Univ, Inst Community Hlth, Odense, Denmark Boston Univ, Sch Med, Dept Environm Hlth, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Dept Environm Hlth, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA Sch Publ Hlth, Boston, MA USA Sch Publ Hlth Boston MA USASch Publ Hlth, Boston, MA USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 4, volume: 10, anno: 1999,
pagine: 370 - 375
SICI:
1044-3983(199907)10:4<370:PMEAAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; METHYL MERCURY; BIRTH-WEIGHT; FOLLOW-UP; HYPERTENSION; CHILDHOOD; PREGNANCY; CHILDREN; GROWTH; MORTALITY;
Keywords:
birth weight; blood pressure; environmental pollution; prenatal exposure delayed effects; preschool child; methylmercury; biomarkers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Grandjean, P Dept Environm Med, Winslowparken 17, DK-5000 Odense 17, Denmark Dept Environm Med Winslowparken 17 Odense Denmark 17 Denmark
Citazione:
N. Sorensen et al., "Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age", EPIDEMIOLOG, 10(4), 1999, pp. 370-375

Abstract

Blood pressure in childhood is an important determinant of hypertension risk later in life, and methylmercury exposure is a potential environmental risk factor. A birth cohort of 1,000 children from the Faroe Islands was examined for prenatal exposure to methylmercury, and at age 1 years, blood pressure, heart rate, and heart rate variability were determined. After adjustment for body weight, diastolic and systolic blood pressure increased by 13.9 mmHg [95% confidence limits (CL) = 7.4, 20.4] and 14.6 mmHg (95% CL = 8.3, 20.8), respectively, when cord blood mercury concentrations increased from 1 to 10 mu g/liter cord blood. Above this level, which corresponds to a current exposure limit, no further increase was seen. Birth weight acted asa modifier, with, the mercury effect bring stronger in children with lowerbirth weights. In boys, heart rate variability decreased with increasing mercury exposures, particularly from 1 to 10 mu g/liter cord blood, at whichthe variability was reduced by 47%, (95% CL = 14%, 68%). These findings suggest that prenatal exposure to methylmercury may affect the development ofcardiovascular homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:12:21