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Titolo:
Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP
Autore:
Konietzko, U; Kauselmann, G; Scafidi, J; Staubli, U; Mikkers, H; Berns, A; Schweizer, M; Waltereit, R; Kuhl, D;
Indirizzi:
Univ Hamburg, Zentrum Mol Neurobiol, ZMNH, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 iol, ZMNH, D-20246 Hamburg, Germany NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
EMBO JOURNAL
fascicolo: 12, volume: 18, anno: 1999,
pagine: 3359 - 3369
SICI:
0261-4189(19990615)18:12<3359:PKEIIB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; TISSUE-PLASMINOGEN ACTIVATOR; PROTEIN-SYNTHESIS; GLUTAMATE RECEPTORS; LATE-PHASE; SYNAPTIC TRANSMISSION; HIPPOCAMPAL SLICES; TRANSGENIC MICE; MEMORY STORAGE;
Keywords:
gene induction; knockout; LTP; Pim kinase; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhl, D Univ Hamburg, Zentrum Mol Neurobiol, ZMNH, Martinistr 52, D-20246 Hamburg,Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 amburg,Germany
Citazione:
U. Konietzko et al., "Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP", EMBO J, 18(12), 1999, pp. 3359-3369

Abstract

In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-l, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke longterm potentiation (LTP), Mice deficient for Pim-l show normal synaptic transmission and short-term plasticity, How ever, they fail toconsolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity, Thus, expression of Pim-l is required for LTP, Its level ofexpression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 13:23:55