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Titolo:
PARTICIPATION OF PRESYNAPTIC NORADRENERGIC FIBERS IN THE SUPPRESSION OF ALPHA(2)-ADRENOCEPTOR ACTIVITY BY SUBSTANCE-P AT THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS OF THE RAT
Autore:
LEN WB; TSOU MY; CHAN SHH; CHAN JYH;
Indirizzi:
VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT MED RES TAIPEI 11217 TAIWAN VET GEN HOSP,DEPT ANESTHESIOL TAIPEI 11217 TAIWAN NATL YANG MING UNIV,CTR NEUROSCI TAIPEI 11221 TAIWAN
Titolo Testata:
Synapse
fascicolo: 4, volume: 21, anno: 1995,
pagine: 357 - 363
SICI:
0887-4476(1995)21:4<357:POPNFI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM PROJECTIONS; BETA-2-ADRENERGIC RECEPTORS; GUANABENZ; CLONIDINE; ALPHA-2-ADRENOCEPTORS; AUTORADIOGRAPHY; MICRODIALYSIS; CARBAMAZEPINE; TRANSMITTER; RESPONSES;
Keywords:
GUANABENZ; NORADRENERGIC NEUROTRANSMISSION; IN VIVO MICRODIALYSIS; DSP4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
W.B. Len et al., "PARTICIPATION OF PRESYNAPTIC NORADRENERGIC FIBERS IN THE SUPPRESSION OF ALPHA(2)-ADRENOCEPTOR ACTIVITY BY SUBSTANCE-P AT THE NUCLEUS-RETICULARIS GIGANTOCELLULARIS OF THE RAT", Synapse, 21(4), 1995, pp. 357-363

Abstract

We applied reverse microdialysis and high performance liquid chromatography (HPLC) analysis to evaluate the participation of presynaptic noradrenergic neurotransmission in the suppression by substance P (SP) of alpha(2)-adrenoceptor activity at the nucleus reticularis gigantocellularis (NRGC) in Sprague-Dawley rats anesthetized with pentobarbital sodium. Microinfusion of SP (600 mu M/min) into the NRGC through a stereotaxically positioned microdialysis probe attenuated the hypotensiveand bradycardiac actions of the alpha(2)-adrenoceptor agonist, guanabenz (100 mu g/kg, i.v.). This inhibitory effect correlated positively with the time course of elevation in the estimated extracellular concentrations of SP and norepinephrine (NE) in the NRGC. Direct microinfusion of NE (50 nM/min) into the NRGC also lessened the cardiosuppressant effects of guanabenz. These circulatory and NE responses to SP were,however, significantly blunted in rats in which the noradrenergic innervation in the NRGC was depleted with N-(2-chloroethyl)-N-ethyl-2-bromobenzyl amine hydrochloride (DSP4) pretreatment. Microinfusion of NE into the NRGC of DSP4-pretreated animals restored the attenuation of guanabenz-induced cardiovascular suppression. These results suggest that SP may depress the activity of alpha(2)-adrenoceptor at the NRGC that are involved in circulatory regulation by increasing the extracellular concentration of NE via a presynaptic modulation of noradrenergic neurotransmission. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 28/09/20 alle ore 05:40:26