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Titolo:
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
Autore:
Kataoka, H; Kume, N; Miyamoto, S; Minami, M; Moriwaki, H; Murase, T; Sawamura, T; Masaki, T; Hashimoto, N; Kita, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto 6068507, JapanKyoto Univ Kyoto Japan 6068507 riatr Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Neurosurg, Kyoto 6068507, Japan Kyoto UnivKyoto Japan 6068507 Med, Dept Neurosurg, Kyoto 6068507, Japan Natl Cardiovasc Ctr, Res Inst, Dept Biosci, Osaka, Japan Natl Cardiovasc Ctr Osaka Japan tr, Res Inst, Dept Biosci, Osaka, Japan
Titolo Testata:
CIRCULATION
fascicolo: 24, volume: 99, anno: 1999,
pagine: 3110 - 3117
SICI:
0009-7322(19990622)99:24<3110:EOLOLL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE SCAVENGER RECEPTOR; INTERCELLULAR-ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL-CELLS; CORONARY ATHEROSCLEROSIS; APOPTOTIC THYMOCYTES; LDL RECEPTOR-1; MESSENGER-RNA; P-SELECTIN; HUMAN CD68; IN-VITRO;
Keywords:
atherosclerosis; cholesterol, LD; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Kume, N Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 oto 6068507, Japan
Citazione:
H. Kataoka et al., "Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions", CIRCULATION, 99(24), 1999, pp. 3110-3117

Abstract

Background-Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis,Lectinlike Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surfacereceptor for Ox-LDL. The relationship of this novel receptor for Ox-LDL toatherogenesis, however, has not yet been clarified. In this study, we explored the expression of LOX-1 in the atherosclerotic lesions of human carotid arteries. Methods and Results-Using carotid endarterectomy specimens obtained from 21 patients and 2 samples of normal human aortas, we examined LOX-1 expression by reverse transcription-polymerase chain reaction and immunohistochemistry. In aortas without atherosclerosis, LOX-1 expression was undetectable by immunohistochemistry and negligible by reverse transcription-polymerase chain reaction. In carotid arteries, luminal endothelial cells covering early atherosclerotic lesions were more frequently positive for LOX-1 expression than those in advanced atherosclerotic lesions, Endothelial cells in the intimal neovasculature of advanced lesions also expressed LOX-1. In addition, macrophages and smooth muscle cells in the intima of advanced atherosclerotic plaques were positive for LOX-1 expression. Conclusions-LOX-1 may play important roles in Ox-LDL uptake and subsequentfunctional alteration in the luminal endothelium in early atherosclerotic lesions and in intimal neovascular endothelial cells in advanced plaques. Furthermore, LOX-1 may also be involved in Ox-LDL uptake and subsequent foamcell transformation in macrophages and smooth muscle cells in the atherosclerotic intima.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/05/20 alle ore 17:32:41