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Titolo:
Expression of a novel member of the TGF-beta superfamily, growth differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues
Autore:
Bottner, M; Suter-Crazzolara, C; Schober, A; Unsicker, K;
Indirizzi:
Univ Heidelberg, Dept Neuroanat, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Sch Med, Inst Neuroanat, D-30625 Hannover, Germany Sch Med Hannover Germany D-30625 st Neuroanat, D-30625 Hannover, Germany
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 1, volume: 297, anno: 1999,
pagine: 103 - 110
SICI:
0302-766X(199907)297:1<103:EOANMO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEINS; CHROMAFFIN CELLS; ADRENAL-GLAND; LOCALIZATION; RECEPTORS; PLACENTA; KIDNEY; GDNF; MICE;
Keywords:
TGF-beta; CNS; epithelial tissues; macrophages; rat (Wistar);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Unsicker, K Univ Heidelberg, Dept Neuroanat, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany Univ Heidelberg Im Neuenheimer Feld 307 HeidelbergGermany D-69120
Citazione:
M. Bottner et al., "Expression of a novel member of the TGF-beta superfamily, growth differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues", CELL TIS RE, 297(1), 1999, pp. 103-110

Abstract

We have cloned a novel member of the transforming growth factor-P (TGF-P) superfamily from a human placental cDNA library. The sequence is identical to five very recently published sequences, of which only one (macrophage inhibitory cytokine-l, MIC-1) has been characterized in terms of function. Inlight of the present data demonstrating the wide distribution of the mRNA and putative multifunctionality, we propose to name this molecule growth/differentiation factor-15/MIC-1 (GDF-15/MIC-1). The deduced amino acid sequence reveals typical features of a secreted molecule. The epithelium of the choroid plexus is the only site in the adult brain expressing detectable levels of GDF-15/MIC-1 mRNA. Many epithelia of non-neural tissues including those of the prostate and intestinal mucosa, bronchi and bronchioli, secretory tubuli of the submandibular gland, and lactating mammary gland are prominent sites of GDF-15/MIC-1 synthesis. GDF-15/MIC-1 is also strongly expressed by macrophages in the adrenal gland. Thus, GDF-15/MIC-1, like many other members of the TGF-P superfamily, is widely distributed in adult tissues, being most strongly expressed in epithelial cells and macrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 16:17:15