Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic high-dose creatine feeding does not attenuate left ventricular remodeling in rat hearts post-myocardial infarction
Autore:
Horn, M; Remkes, H; Dienesch, C; Hu, K; Ertl, G; Neubauer, S;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Heidelberg, Klinikum Mannheim, Abt Kardiol, Heidelberg, Germany Univ Heidelberg Heidelberg Germany im, Abt Kardiol, Heidelberg, Germany
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 1, volume: 43, anno: 1999,
pagine: 117 - 124
SICI:
0008-6363(199907)43:1<117:CHCFDN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DECREASED ENERGY RESERVE; P-31 MAGNETIC-RESONANCE; DILATED CARDIOMYOPATHY; MECHANICAL FUNCTION; CARDIAC-FAILURE; KINASE SYSTEM; METABOLISM; MUSCLE; PHOSPHATE; ENDOTHELIN-1;
Keywords:
creatine; P-31 NMR spectroscopy; heart failure; ATP; phosphocreatine; isolated rat heart;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Neubauer, S Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
M. Horn et al., "Chronic high-dose creatine feeding does not attenuate left ventricular remodeling in rat hearts post-myocardial infarction", CARDIO RES, 43(1), 1999, pp. 117-124

Abstract

Objective: In heart failure, cardiac energy metabolism is compromised. Thefailing myocardium is characterized by reduced contents of both phosphorylated (phosphocreatine) and non-phosphorylated (free) creatine content as well as decreased energy reserve via creatine kinase (creatine kinase reaction velocity). These changes may contribute to cardiac dysfunction. The purpose of the present study was to determine whether chronic feeding with high-dose dietary creatine prevents the derangement of energy metabolism and thedevelopment of left ventricular remodeling in a rat model of heart failure, i.e. post-myocardial infarction (MI). Methods and results: Rats were subjected to sham operation or left coronary artery ligation. Surviving rats were fed with 0% (untreated) or 3% creatine (related to weight of diet) for 8weeks. Creatine feeding increased serum creatine levels significantly similar to 2-fold. Thereafter, hearts were isolated, perfused and left ventricular pressure-volume curves obtained. Steady state and dynamic (CK reaction velocity) high-energy phosphate metabolism was determined with P-31 NMR spectroscopy. In both MI groups (treated n=8, untreated n=7), pressure-volume curves were shifted right- and downward compared to both sham groups (treated n=5, untreated 11=7), i.e. creatine had no effect on left ventricular remodeling. Likewise, similar reductions of phosphocreatine, free creatine and creatine kinase reaction velocity (untreated sham 12.0+/-0.7 mmol/1Xs; untreated MI 7.8+/-0.7*; treated sham 13.6+/-1.0; treated MI 7.2+/-1.1*; *p<0.025 sham vs. MI) were found in both MI groups. Conclusions: Chronic creatine feeding of post-MI rats is ineffective in preventing the functional and energetic derangements occurring post-MI. Inspite of increased serum creatine levels, neither the normal nor the failing heart accumulates additional creatine. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:28:14