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Titolo:
Chemopreventive activity of very low dose dietary tannic acid administration in hepatoma bearing C3H male mice
Autore:
Nepka, C; Sivridis, E; Antonoglou, O; Kortsaris, A; Georgellis, A; Taitzoglou, I; Hytiroglou, P; Papadimitriou, C; Zintzaras, I; Kouretas, D;
Indirizzi:
Univ Thessaly, Fac Agr, Pedion Areos, Pedion Areos, Volos, Greece Univ Thessaly Pedion Areos Volos Greece eos, Pedion Areos, Volos, Greece Cytopathol Lab, Serres 62100, Greece Cytopathol Lab Serres Greece 62100Cytopathol Lab, Serres 62100, Greece Democritus Univ Thrace, Sch Med, Alexandroupolis, Greece Democritus Univ Thrace Alexandroupolis Greece , Alexandroupolis, Greece Theagen Canc Hosp, Salonika, Greece Theagen Canc Hosp Salonika GreeceTheagen Canc Hosp, Salonika, Greece Res Ctr Environm Illness, Huddinge, Sweden Res Ctr Environm Illness Huddinge Sweden ronm Illness, Huddinge, Sweden Aristotelian Univ Salonika, Sch Med, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Univ Thessaly, Fac Vet Sci, Karditsa, Greece Univ Thessaly Karditsa Greece v Thessaly, Fac Vet Sci, Karditsa, Greece
Titolo Testata:
CANCER LETTERS
fascicolo: 1-2, volume: 141, anno: 1999,
pagine: 57 - 62
SICI:
0304-3835(19990701)141:1-2<57:CAOVLD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
(-)-EPIGALLOCATECHIN GALLATE; TEA POLYPHENOLS; GREEN TEA; F344 RATS; INHIBITION; INDUCTION; APOPTOSIS; PROMOTION; LESIONS; CELLS;
Keywords:
tannins; tannic acid; hepatocarcinogenesis; chemoprevention; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kouretas, D Univ Thessaly, Fac Agr, Pedion Areos, Pedion Areos, Volos, Greece Univ Thessaly Pedion Areos Volos Greece Areos, Volos, Greece
Citazione:
C. Nepka et al., "Chemopreventive activity of very low dose dietary tannic acid administration in hepatoma bearing C3H male mice", CANCER LETT, 141(1-2), 1999, pp. 57-62

Abstract

Tannins are plant polyphenols comprising a heterogeneous group of compounds. Tannic acid is a common tannin found in tea, coffee, immature fruits, etc. and it has also been used as a food additive. An increasing body of experimental evidence supports the hypothesis that tannins exert anticarcinogenic activity in chemically induced cancers in animal models. in the present study, tannic acid was administered in very low doses in the drinking waterof C3H male mice divided into three groups (75 mg/l, 150 mg/l and 300 mg/l), These animals carry a genetic defect and show a high incidence of spontaneous liver tumors ( > 50%) at an age older than 12 months. The results showed a decrease in the overall incidence of hepatic neoplasms (adenomas pluscarcinomas): 53.3% of animals in the control group developed hepatic neoplasms Versus 33.3% in the group given a low dose of tannic acid 26.6% in thegroup given a medium dose and 13.3% in the high dosage group. The difference was more pronounced in the animals with carcinomas: 4.44% of mice who received tannic acid developed carcinomas versus 33.3% of those in the control group. Tannic acid administration did not affect the PCNA labeling index of normal hepatocytes. It is concluded that tannic acid dietary intake in low doses can exert a strong dose-dependent chemoprotective activity againstspontaneous hepatic neoplasm development in C3H male mice, most probably through antipromoting mechanisms. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:44:08