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Titolo:
Effect of a single bolus of intracoronary basic fibroblast growth factor on perfusion in an ischemic porcine model
Autore:
Devlin, GP; Fort, S; Yu, E; Cusimano, RJ; Wei, K; Rakowski, H; Butany, J; Richards, JA; Sole, MJ; Schwartz, L;
Indirizzi:
Univ Toronto, Dept Med, Div Cardiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada ept Med, Div Cardiol, Toronto, ON, Canada
Titolo Testata:
CANADIAN JOURNAL OF CARDIOLOGY
fascicolo: 6, volume: 15, anno: 1999,
pagine: 676 - 682
SICI:
0828-282X(199906)15:6<676:EOASBO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY; COLLATERAL BLOOD-FLOW; EXTRACELLULAR-MATRIX; CANINE MODEL; RAT-HEART; ANGIOGENESIS; LOCALIZATION; INJURY; INFARCTION;
Keywords:
angiogenesis; growth substances; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Devlin, GP Waikato Hosp, Dept Cardiol, Private Bag,Pembroke St, Hamilton, New Zealand Waikato Hosp Private Bag,Pembroke St Hamilton New Zealand and
Citazione:
G.P. Devlin et al., "Effect of a single bolus of intracoronary basic fibroblast growth factor on perfusion in an ischemic porcine model", CAN J CARD, 15(6), 1999, pp. 676-682

Abstract

Basic fibroblast growth factor (bFGF) has been shown to induce angiogenesis in various animal models, but the methods of administration used experimentally are not clinically feasible. The objective of this study was to determine whether a single intracoronary bolus injection of bFGF would improve coronary perfusion in a porcine ischemic model that mimics clinical chronicischemia. A copper coil studded with gold was delivered into the proximal right coronary artery of juvenile Yorkshire pigs and deployed by interventional techniques. After a four-week interval for stenosis maturation, bFGF (100 mu g) was administered by bolus injection into the left coronary arteryin five animals, and vehicle alone was administered in four animals. Angiogenesis and change in right coronary perfusion area were assessed two weekslater by angiography, myocardial contrast echocardiography and immunohistochemistry. The right coronary perfusion area increased significantly after treatment in all but one of the animals that received bFGF but not in any of the controls. Intimal hyperplasia was not induced by bFGF. Capillary density determined histochemically was not different in the two groups. In conclusion, in a porcine ischemic model, bFGF administered by a single bolus intracoronary injection into the contralateral artery improved antegrade perfusion into the ischemic territory although without histological evidence ofangiogenesis. This preliminary work merits further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:56:08