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Titolo:
Clinical significance of telomerase activity in the non-cancerous epithelial region of oesophageal squamous cell carcinoma
Autore:
Koyanagi, K; Ozawa, S; Ando, N; Takeuchi, H; Ueda, M; Kitajima, M;
Indirizzi:
Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 pt Surg, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
BRITISH JOURNAL OF SURGERY
fascicolo: 5, volume: 86, anno: 1999,
pagine: 674 - 679
SICI:
0007-1323(199905)86:5<674:CSOTAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; GENETIC DIAGNOSIS; IMMORTAL CELLS; FIBROBLASTS; SENESCENCE; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, M Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 okyo 1608582, Japan
Citazione:
K. Koyanagi et al., "Clinical significance of telomerase activity in the non-cancerous epithelial region of oesophageal squamous cell carcinoma", BR J SURG, 86(5), 1999, pp. 674-679

Abstract

Background: The aim of this study was to examine telomerase activity in affected and adjacent tissue in patients with oesophageal squamous cell carcinoma (SCC). Methods: Telomerase activity was measured in oesophageal SCC cells, normaloesophageal culture cells, primary cancer tissues and adjacent normal tissues from patients with oesophageal SCC using a polymerase chain reaction-based assay. Results: All oesophageal SCC cells had telomerase activity, whereas normalcultured cells showed no activity. All 57 cancer tissues showed telomeraseactivity compared with only five (10 per cent) of 50 normal tissues. Cancer cells infiltrating the vessels of mucosal or submucosal tissues in non-cancerous regions were detected in four of five telomerase-positive normal tissues, whereas such infiltration was detected in only three of 45 telomerase-negative normal tissues. Conclusion: In patients with oesophageal SCC, measurement of telomerase activity in normal epithelium is a highly sensitive method of detecting the microinvasion of cancer cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 01:34:33