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Titolo:
Elevation of CD5(+) B lymphocytes in schizophrenia
Autore:
Printz, DJ; Strauss, DH; Goetz, R; Sadiq, S; Malaspina, D; Krolewski, J; Gorman, JM;
Indirizzi:
New York State Psychiat Inst, Dept Clin Psychobiol, New York, NY 10032 USANew York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10027 USA Columbia Univ New York NY USA 10027 , Dept Neurol, New York, NY 10027 USA Columbia Univ, Coll Phys & Surg, Dept Immunol, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Dept Immunol, New York, NY 10027 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 46, anno: 1999,
pagine: 110 - 118
SICI:
0006-3223(19990701)46:1<110:EOCBLI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS EXPRESSING CD5; RHEUMATOID-ARTHRITIS; SJOGRENS-SYNDROME; PERIPHERAL-BLOOD; SUB-POPULATIONS; HIGH-AFFINITY; T-CELLS; ANTIBODIES; AUTOANTIBODIES; INTERLEUKIN-2;
Keywords:
schizophrenia; autoimmunity; CD5(+) B lymphocyte; antipsychotic; pathophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Printz, DJ 1051 Riverside Dr,Unit 55, New York, NY 10032 USA 1051 Riverside Dr,Unit 55 New York NY USA 10032 , NY 10032 USA
Citazione:
D.J. Printz et al., "Elevation of CD5(+) B lymphocytes in schizophrenia", BIOL PSYCHI, 46(1), 1999, pp. 110-118

Abstract

Background: A variety of immunologic alterations have been observed in patients with schizophrenia. These findings halle lent support to theories that autoimmune mechanisms may be important in some patients with the illness. The CD5(+) B lymphocyte, a B-cell subset associated with autoimmune disease, has been the subject of two previously published studies yielding disparate results. Methods: In this study we used immunofluorescent flow cytometry to measureCD5(+) B cells, total B and T cells, and CD4 and CD8 subsets in patients with schizophrenia and in normal control subjects. Results: A significantly higher percentage of patients with schizophrenia,relative to normal control subjects, exhibited ail elevated level of CD5(+) B cells (27.6% vs 6.7%). Antipsychotic withdrawal had no effect on CD5(+)B-cell levels, suggesting that medication effects were nor the cause of this difference. Na other studied lymphocyte subsets differed between the twogroups. Conclusions: A subset of patients with schizophrenia have elevated levels of CD5(+) B cells. This finding replicates an earlier study by another group and provides further evidence suggestive of autoimmune manifestations in schizophrenia, (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:55:45