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Titolo:
Elementary phenotypes in the neurobiological and genetic study of schizophrenia
Autore:
Adler, LE; Freedman, R; Ross, RG; Olincy, A; Waldo, MC;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO USA Univ Colorado Denver CO USA Hlth Sci Ctr, Dept Psychiat, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80220 USA Univ Colorado Denver CO USA 80220 tr, Dept Psychiat, Denver, CO 80220 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 46, anno: 1999,
pagine: 8 - 18
SICI:
0006-3223(19990701)46:1<8:EPITNA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY-EVOKED-RESPONSES; SENSORY GATING DEFICITS; CHILDHOOD-ONSET SCHIZOPHRENIA; ALPHA-BUNGAROTOXIN-BINDING; EYE TRACKING DYSFUNCTION; HUMAN POSTMORTEM BRAIN; P50 SUPPRESSION; SMOOTH-PURSUIT; NICOTINIC RECEPTORS; RAT HIPPOCAMPUS;
Keywords:
neuronal inhibition; schizophrenia physiology; eye movements; auditory evoked potentials; genetic segregation; childhood-onset schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, LE Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Campus Box C268-16,4200 E 9th Ave, Denver, CO USA Univ Colorado Campus Box C268-16,4200 E 9th Ave Denver CO USA A
Citazione:
L.E. Adler et al., "Elementary phenotypes in the neurobiological and genetic study of schizophrenia", BIOL PSYCHI, 46(1), 1999, pp. 8-18

Abstract

This review describes the strategy of using elementary phenotypes for neurobiological and genetic linkage studies of schizophrenia. The review concentrates oil practical aspects of selecting the phenotype and then understanding the confounds in its measurement and interpretation, Examples from the authors' studies of deficits in P50 inhibition and smooth pursuit eye movement dysfunction are presented. These two phenotypes share considerable similarity in their neurobiology, including a similar response to nicotine. They also appear to co-segregate with the genetic risk for schizophrenia as autosomal co-dominant phenotypes. Although most schizophrenic patients inherit these abnormalities unilinealy, ie., from one parent, apparent bilineal inheritance produces a more severe illness, observed clinically as childhood-onset schizophrenia. The initial study showing linkage of the P50 deficit to the chromosome 15q14 locus of the alpha 7-nicotinic acetylcholine receptor is an example of the potential usefulness of these phenotypes for combined generic and neurobiological study of schizophrenia. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:38:34