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Titolo:
Application of temperature-sensitive mutations to oncogene studies in Drosophila
Autore:
Baek, KH;
Indirizzi:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, Boston, MA02115 USA Harvard Univ Boston MA USA 02115 t, Div Pediat Oncol, Boston, MA02115 USA
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 3, volume: 22, anno: 1999,
pagine: 229 - 231
SICI:
0253-6269(199906)22:3<229:AOTMTO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; II HEAVY-CHAIN; RECESSIVE ONCOGENE; MELANOGASTER; HOMOLOG; L(2)GL; MAPS;
Keywords:
lethal (2) giant larvae; cadherin; cell adhesion molecule; intragenic complementation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Baek, KH Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Pediat Oncol, 44 Binney St, Boston, MA 02115 USA Harvard Univ 44 Binney St Boston MA USA 02115 oston, MA 02115 USA
Citazione:
K.H. Baek, "Application of temperature-sensitive mutations to oncogene studies in Drosophila", ARCH PH RES, 22(3), 1999, pp. 229-231

Abstract

Recessive oncogenes are genetic functions important in the regulation of tissue growth and differentiation. These genetic functions are defined on the basis of the phenotype expressed by homozygotes. Defining the role of these genes in normal developmental and physiological processes is important to the development of accurate models of the normal regulation of growth anddifferentiation. Drosophila can be a good system to investigate the neoplastic mechanism of oncogenes and provide a greater understanding in the developmental progression of both invertebrates and vertebrates. The lethal (2)giant larvae gene is a recessive oncogene of Drosophila and temperature sensitive mutations of this gene have been isolated. Here, the application oftemperature-sensitive mutations in Drosophila oncogene studies is discussed.

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Documento generato il 30/11/20 alle ore 03:30:46