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Titolo:
Laser-induced thermotherapy combined with hepatic arterial embolization inthe treatment of liver tumors in a rat tumor model
Autore:
Germer, CT; Isbert, C; Albrecht, D; Roggan, A; Pelz, J; Ritz, JP; Muller, G; Buhr, HJ;
Indirizzi:
Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Visceral Vasc & Thorac Surg, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200ac Surg, D-12200 Berlin, Germany Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Inst Med Phys Laser Med,D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 aser Med,D-12200 Berlin, Germany
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 1, volume: 230, anno: 1999,
pagine: 55 - 62
SICI:
0003-4932(199907)230:1<55:LTCWHA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEGRADABLE STARCH MICROSPHERES; INFLOW OCCLUSION; CHEMO-OCCLUSION; METASTASES; HYPERTHERMIA; COAGULATION; TISSUE; HEAT; EFFICACY; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Germer, CT Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept VisceralVasc & Thorac Surg, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 many
Citazione:
C.T. Germer et al., "Laser-induced thermotherapy combined with hepatic arterial embolization inthe treatment of liver tumors in a rat tumor model", ANN SURG, 230(1), 1999, pp. 55-62

Abstract

ObjectiveTo assess the effect of combined laser-induced thermotherapy (LITT) and hepatic arterial embolization with degradable starch microspheres (DSM) on tumor response and intrahepatic temperature distribution in rats with liver tumors. Summary Background DataLaser-induced thermotherapy is a promising in situ ablation technique for malignant liver tumors. However, clinical use is still limited, mainly because of the small size of the inducible coagulation necroses. This results in insufficient tumor destruction. MethodsColon carcinoma CC531 was implanted in 60 WAG rat livers. Fourteen days later, a silicon catheter was implanted in the hepatic artery for DSM administration. Tumors were exposed to 1064 nm Nd:YAG laser light at 2 watts for 10 minutes from a diffuser tip applicator placed in the tumor. The animals were randomized into a sham-operated control (group I) and three test groups. Group ii received DSM alone, group III received LITT alone, and group IV received DSM + LITT. Tumor control was examined 1, 7, and 14 days after treatment. ResultsA complete tumor remission was achieved in all rats treated with LITT + DSM (group IV). In contrast, tumor progression was seen in animals treated with LITT alone (group III) or DSM alone (group II), as well as in the sham-operated controls (group I). ConclusionsThe authors' results suggest that the combination of LITT and DSM considerably increases the efficacy of LITT in the treatment of liver metastases inthe rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:48:02