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Titolo:
Effect of androgens on the cranial suspensory ligament and ovarian position
Autore:
Lee, SMY; Hutson, JM;
Indirizzi:
Royal Childrens Hosp, Dept Gen Surg, Parkville, Vic 3052, Australia Royal Childrens Hosp Parkville Vic Australia 3052 le, Vic 3052, Australia Royal Childrens Hosp, F Douglas Stephens Surg Res Lab, Melbourne, Vic, Australia Royal Childrens Hosp Melbourne Vic Australia , Melbourne, Vic, Australia
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 3, volume: 255, anno: 1999,
pagine: 306 - 315
SICI:
0003-276X(19990701)255:3<306:EOAOTC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; FEMINIZATION; RATS; GUBERNACULUM; FLUTAMIDE; MICE;
Keywords:
cranial suspensory ligament; androgen; ovary; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hutson, JM Royal Childrens Hosp, Dept Gen Surg, Flemington Rd, Parkville, Vic 3052, Australia Royal Childrens Hosp Flemington Rd Parkville Vic Australia 3052
Citazione:
S.M.Y. Lee e J.M. Hutson, "Effect of androgens on the cranial suspensory ligament and ovarian position", ANAT REC, 255(3), 1999, pp. 306-315

Abstract

Androgens have been postulated to have a major role in testicular descent via regression of the cranial suspensory ligament, which in normal rodents anchors the ovary to the retroperitoneum near the lower pole of the kidney. This study aimed to quantitate the degree of descent of the foetal ovary in androgen-treated female mice to determine the role of androgens in regression of the cranial suspensory ligament and descent of the testis. Time-pregnant mice were injected with testosterone propionate or methyl testosterone (2.5-3.0 mg) in vehicle on day 13 or 14. Control animals received vehicleonly. Newborn mice were anaesthetised and dissected for macroscopic anatomy of the ovary, which was quantified by measuring the vertical distance fi om the lower pole of the kidney to the lower pole of the ovary. Histological analysis was also performed. The external genitalia were masculinised in all females exposed to prenatal androgens. The ovaries of treated animals were mobile, with no cranial suspensory Ligament, and located slightly caudal to the kidney. Wolffian duct structures were identifiable, but the gubernaculum was qualitatively unchanged compared with control females. The ovarywas displaced caudally (P < 0.001), but only 15-25% of the distance to thelower abdomen. Exogenous androgens induce regression of the cranial suspensory ligament, causing the ovary to be more mobile and lower in the abdominal cavity. However, since the testicular position at birth is at or below the bladder neck, androgen-mediated regression of the cranial suspensory ligament is only an adjunct to the control of transabdominal testicular descent. Anat Rec 55:306-315, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:53:41