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Titolo:
TROPHIC EFFECTS OF GLICENTIN ON RAT SMALL-INTESTINAL MUCOSA IN-VIVO AND IN-VITRO
Autore:
MYOJO S; TSUJIKAWA T; SASAKI M; FUJIYAMA Y; BAMBA T;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 2 OTSU SHIGA 52021 JAPAN
Titolo Testata:
Journal of gastroenterology
fascicolo: 3, volume: 32, anno: 1997,
pagine: 300 - 305
SICI:
0944-1174(1997)32:3<300:TEOGOR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; ORNITHINE DECARBOXYLASE; ENTEROGLUCAGON; RESECTION; PROLIFERATION; PROGLUCAGON; SECRETION; PANCREAS; PEPTIDES; PROTEIN;
Keywords:
ENTEROGLUCAGON; GLICENTIN; ORNITHINE DECARBOXYLASE (ODC); RAT SMALL INTESTINE; IEC-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Myojo et al., "TROPHIC EFFECTS OF GLICENTIN ON RAT SMALL-INTESTINAL MUCOSA IN-VIVO AND IN-VITRO", Journal of gastroenterology, 32(3), 1997, pp. 300-305

Abstract

To define the role of glicentin the active site of enteroglucagon, weevaluated the trophic effects of recombinant rat glicentin on rat small intestine and IEC-6 cells. In vivo, a significant increase was observed in jejunal wet weight, protein content, DNA content, and alkalinephosphatase activity after the subcutaneous administration of 100 mu g/kg per day of glicentin for 2 weeks. In the ileum. however, there were no significant differences between the control versus glicentin groups in any of these parameters. Ornithine decarboxylase (ODC) activity3.5 h after an intraperitoneal injection of glicentin was increased in the jejunal mucosa, but not in the ileal mucosa. In vitro, glicentin, at a dose of more than 100 ng/ml, significantly increased both tritium-thymidine incorporation and the number of IEC-G cells. These findings indicate that glicentin exerts direct trophic effects on the rat small-intestinal mucosa and on the rat small-intestinal cell line, IEC-6, and that this peptide appears to be an active site of enteroglucagon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:19:36