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Titolo:
Usefulness of UniCAP-tryptase fluoroimmunoassay in the diagnosis of anaphylaxis
Autore:
Enrique, E; Garcia-Ortega, P; Sotorra, O; Gaig, P; Richart, C;
Indirizzi:
Univ Rovira & Virgili, Hosp Joan XXIII, Dept Internal Med, Allergy Unit, Tarragona 43007, Spain Univ Rovira & Virgili Tarragona Spain 43007 Unit, Tarragona 43007, Spain
Titolo Testata:
ALLERGY
fascicolo: 6, volume: 54, anno: 1999,
pagine: 602 - 606
SICI:
0105-4538(199906)54:6<602:UOUFIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELL ACTIVATION; SERUM TRYPTASE; IDIOPATHIC ANAPHYLAXIS; SYSTEMIC-ANAPHYLAXIS; MASTOCYTOSIS; ALPHA;
Keywords:
allergy diagnosis; anaphylaxis; tryptase fluoroimmunoassay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Ortega, P Univ Rovira & Virgili, Hosp Joan XXIII, Dept Internal Med, Allergy Unit, Av Dr Mallafre Guasc 4, Tarragona 43007, Spain Univ Rovira & Virgili Av Dr Mallafre Guasc 4 Tarragona Spain 43007
Citazione:
E. Enrique et al., "Usefulness of UniCAP-tryptase fluoroimmunoassay in the diagnosis of anaphylaxis", ALLERGY, 54(6), 1999, pp. 602-606

Abstract

Background: Serum tryptase level measured by RIA is the main in vitro toolto confirm the diagnosis of anaphylaxis. Methods: Serum tryptase levels were determined by UniCAP-Tryptase fluoroimmunoassay (Pharmacia & Upjohn, Uppsala, Sweden), in 30 consecutive patientswho presented at the emergency room with a clinical allergic reaction of less than 6-h duration to assess the value of this method in the diagnosis of anaphylaxis. Anaphylaxis was established by clinical criteria and by immunoallergic study. Baseline tryptase levels were determined 1 month later in21 patients. The receiver operating curve (ROC) was used to establish the best cutoff point of tryptase levels to confirm the diagnosis of anaphylaxis. Results: Seventeen patients were diagnosed with anaphylaxis. In this group, tryptase levels were higher than in the nonanaphylaxis group, composed mostly of patients with urticaria or angioedema (P<0.001). ROC established the best cutoff of tryptase levels at 8.23 ng/ml with a 94.12% sensitivity and 92.31% specificity, whereas the 13.5 ng/ml cutoff recommended by the manufacturers showed 35.29% sensitivity and 92.31% specificity. The reaction-tryptase/baseline-tryptase ratio was 2.85 in the anaphylaxis group and 1.29 in the nonanaphylaxis group. Conclusions: Serum tryptase levels of >8.23 ng/ml by UniCAP-Tryptase fluoroimmunoassay identify anaphylaxis in patients with symptoms of less than 6-h duration. The usefulness of this determination is higher if baseline tryptase levels are available.

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Documento generato il 27/01/21 alle ore 01:27:50