Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association of plasma levels of activated protein C with recanalization ofthe infarct-related coronary artery after thrombolytic therapy in acute myocardial infarction
Autore:
Takazoe, K; Ogawa, H; Yasue, H; Sakamoto, T; Oshima, S; Arai, H; Moriyama, Y; Shimomura, H; Hirai, N; Kaikita, K; Soejima, H; Misumi, K; Hosoda, K;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan Fukuoka Tokushukai Hosp, Div Cardiol, Fukuoka, Japan Fukuoka Tokushukai Hosp Fukuoka Japan Hosp, Div Cardiol, Fukuoka, Japan Teijin Ltd, Tokyo, Japan Teijin Ltd Tokyo JapanTeijin Ltd, Tokyo, Japan
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 1, volume: 95, anno: 1999,
pagine: 37 - 47
SICI:
0049-3848(19990701)95:1<37:AOPLOA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; INHIBITOR ACTIVITY; FIBRINOPEPTIDE-A; THROMBIN LEVELS; T-PA; BLOOD; REOCCLUSION; COAGULATION; PREVENTION; MECHANISM;
Keywords:
myocardial infarction; thrombolysis; activated protein C; thrombin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ogawa, H Kumamoto Univ, Sch Med, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8608556 mamoto 8608556,
Citazione:
K. Takazoe et al., "Association of plasma levels of activated protein C with recanalization ofthe infarct-related coronary artery after thrombolytic therapy in acute myocardial infarction", THROMB RES, 95(1), 1999, pp. 37-47

Abstract

Protein C is one of the most important antithrombotic components. After activation by the thrombin-thrombomodulin complex on endothelial cells, activated protein C (APC) inactivates factors Va and VIIIa, which leads to the inhibition of thrombin formation. We examined the association of plasma levels of APC with the responsiveness to coronary thrombolytic therapy of the infarct-related coronary artery in patients with acute myocardial infarction(AMI). Plasma levels of APC, thrombin-antithrombin III complex (TAT), and plasminogen activator inhibitor (PAI) activity were measured in 32 consecutive AMI patients who underwent coronary angiography followed by thrombolytic therapy, and compared to the measurements in 23 control subjects. On admission, APC levels (ng/mL) were significantly elevated in patients with AMI,as compared with controls (2.5+/-0.4 vs. 1.2+/-0.2, 1.3+/-0.2, respectively, p<0.01). At discharge, plasma levels in AMI patients decline to values not significantly different from those in controls. (1.2+/-0.2, 1.3+/-0.2, respectively). TAT levels (ng/mL) were different among the groups in a fashion similar to that of APC (14.1+/-3.1 on admission vs. 3.3+/-0.4 at discharge, 1.8+/-0.1 in the control subjects, respectively, p<0.01). PAI activity levels (IU/mL) were higher on admission than at discharge and higher than the control subjects (19.7+/-1.8 vs. 10.5+/-1.0, 5.4+/-0.7, respectively, p<0.01). Thirty-two patients with AMI were classified into two groups according to the results of thrombolysis: the success group (24 patients) and the failure group (eight patients). APC levels were higher in the failure groupthan in the success group (5.1+/-0.7 vs. 1.6+/-0.2, p<0.01). TAT levels were also higher in the failure group than in the success group (30.8+/-9.6 vs. 8.6+/-1.7, p<0.01). PAI activity levels (IU/mL) were lower in the failure group than in the success group (13.5+/-3.1 vs. 21.7+/-2.1,p<0.05). Therewere correlations between APC and TAT levels both on admission (r=0.75, p<0.0001) and at discharge (r=0.71,p<0.0001). Elevated APC was thought to correlate with increased thrombin generation in patients with AMI. This study demonstrated that there was a significant relation between plasma APC leveland the responsiveness to thrombolytic therapy of the infarct artery. Thisstudy may also indicate that increased thrombin generation is a cause of the resistance to thrombolytic therapy. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:55:45