Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Enantiomeric synthesis of L- (or 1S,2R,3S,5S)-bicarbocyclic[3.1.0] nucleosides
Autore:
Agrofoglio, LA; Demaison, C; Toupet, L;
Indirizzi:
Fac Sci, CNRS, ICOA, F-45100 Orleans, France Fac Sci Orleans France F-45100 Sci, CNRS, ICOA, F-45100 Orleans, France Univ Rennes 1, Grp Mat Condensee & Mat, CNRS, F-35042 Rennes, France Univ Rennes 1 Rennes France F-35042 & Mat, CNRS, F-35042 Rennes, France
Titolo Testata:
TETRAHEDRON
fascicolo: 26, volume: 55, anno: 1999,
pagine: 8075 - 8082
SICI:
0040-4020(19990625)55:26<8075:ESOL(1>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; POTENTIAL ANTIVIRAL DRUGS; HEPATITIS-B VIRUS; CARBOCYCLIC NUCLEOSIDES; STEREOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; ANALOGS; CLITOCINE; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Agrofoglio, LA Fac Sci, CNRS, ICOA, F-45100 Orleans, France Fac Sci Orleans France F-45100 A, F-45100 Orleans, France
Citazione:
L.A. Agrofoglio et al., "Enantiomeric synthesis of L- (or 1S,2R,3S,5S)-bicarbocyclic[3.1.0] nucleosides", TETRAHEDRON, 55(26), 1999, pp. 8075-8082

Abstract

The total synthesis of L- (or 1S,2R,3S,5S)-bicarbocyclic nucleosides (8-15) has been accomplished. The key intermediate 3 was synthesized in two steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions and its X-ray structure has been determined. The derivative 4 was utilized to obtain thymine derivative (8). Amine exocyclic pyrimidine (9-12) and purine (13-15) bicarbocyclic L-nucleosides were obtained from the (IS,2R,3S,5S)-2-(3-aminobicyclo[3.1.0]hex-2-yl)ethanol (7). (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:21:23