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Titolo:
INTERLEUKIN-6 SECRETING PHEOCHROMOCYTOMA ASSOCIATED WITH CLINICAL MARKERS OF INFLAMMATION
Autore:
TAKAGI M; EGAWA T; MOTOMURA T; SAKUMAMOCHIZUKI J; NISHIMOTO N; KASAYAMA S; HAYASHI S; KOGA M; YOSHIZAKI K; YOSHIOKA T; OKUYAMA A; KISHIMOTO T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT MED 3,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT UROL SUITA OSAKA 565 JAPAN
Titolo Testata:
Clinical endocrinology
fascicolo: 4, volume: 46, anno: 1997,
pagine: 507 - 509
SICI:
0300-0664(1997)46:4<507:ISPAWC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHEOCHROMOCYTOMA; EXPRESSION; IL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Takagi et al., "INTERLEUKIN-6 SECRETING PHEOCHROMOCYTOMA ASSOCIATED WITH CLINICAL MARKERS OF INFLAMMATION", Clinical endocrinology, 46(4), 1997, pp. 507-509

Abstract

Phaeochromocytomas have been shown to produce not only catecholaminesbut other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70-year-old female patient with phaeochromocytoma exhibiting sustained hypertension, low-grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C-reactive protein. Serum interleukin (IL)-6 levels were significantly elevated, whereas serum lL-1 alpha and IL-1 beta were not detectable. After surgical removalof the tumour, hypertension and low-grade fever disappeared, and the laboratory findings including serum IL-6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL-6. Culture of the resected tumour revealed the production of large amounts of IL-6. It is suggested that IL-6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:23:30