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Titolo:
Skeletal muscle mitochondrial function in polymyalgia rheumatica and in giant cell arteritis
Autore:
Miro, O; Casademont, J; Jarreta, D; Grau, JM; Urbano-Marquez, A; Cardellach, F;
Indirizzi:
Univunyerelona, Dept Internal Med, Muscle Res Unit,Hosp Clin, August Pi & S Univ Barcelona Barcelona Catalonia Spain 08036 t,Hosp Clin, August Pi & S
Titolo Testata:
RHEUMATOLOGY
fascicolo: 6, volume: 38, anno: 1999,
pagine: 568 - 571
SICI:
1462-0324(199906)38:6<568:SMMFIP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOPATHY;
Keywords:
polymyalgia rheumatica; giant cell arteritis; mitochondria; ragged-red fibres; electron transport chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Cardellach, F Univunyerelona,Spain Internal Med, Muscle Res Unit,Hosp Clin, August Pi & S Univ Barcelona Villarroel 170 Barcelona Catalonia Spain 08036
Citazione:
O. Miro et al., "Skeletal muscle mitochondrial function in polymyalgia rheumatica and in giant cell arteritis", RHEUMATOLOG, 38(6), 1999, pp. 568-571

Abstract

Objective. To ascertain whether mitochondrial function is impaired in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). Patients and methods. Thirteen patients suffering from isolated PMR, 19 from GCA (eight with and 11 without PMR) and 25 healthy people submitted to orthopaedic surgery were included. Skeletal muscle was obtained from the quadriceps by open biopsy. Mitochondrial histological abnormalities were assessed on Gomori's trichrome staining and on cytochrome c oxidase and succinicdehydrogenase reactions. Biochemical studies consisted of polarographic measurement of oxidative activity using complex I, II, III and IV substrates,and spectrophotometric determination of individual enzymatic activity of such complexes. Results. We did not find differences among groups either with respect to the percentage of histological or histochemical abnormalities [P = not significant (NS) for all stainings and reactions], oxidative capacity (P = NS for all substrates) or individual enzymatic activities (P = NS For all complexes). Conclusion. Skeletal muscle mitochondria remain histologically and functionally unaffected in PMR and in GCA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:45:37