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Titolo:
Molecular modelling of the 5-hydroxytryptamine receptors
Autore:
Wishart, G; Bremner, DH; Sturrock, KR;
Indirizzi:
Univ London Univ Coll, Wolfson Inst Biomed Res, London WC1H 0AJ, England Univ London Univ Coll London England WC1H 0AJ , London WC1H 0AJ, England Univ Abertay Dundee, Sch Mol & Life Sci, Div Chem, Dundee DD1 1HG, Scotland Univ Abertay Dundee Dundee Scotland DD1 1HG em, Dundee DD1 1HG, Scotland
Titolo Testata:
RECEPTORS & CHANNELS
fascicolo: 4, volume: 6, anno: 1999,
pagine: 317 - 335
SICI:
1060-6823(1999)6:4<317:MMOT5R>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; SITE-DIRECTED MUTAGENESIS; SEROTONIN 5-HT RECEPTORS; LIGAND-BINDING SITE; 3-DIMENSIONAL MODELS; AGONIST BINDING; BETA-2-ADRENERGIC RECEPTOR; ELECTRON CRYOMICROSCOPY; TRANSMEMBRANE HELICES; PROJECTION STRUCTURE;
Keywords:
5-hydroxytryptamine; molecular models; receptors; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Wishart, G UnivGordonn Univ Coll, Wolfson Inst Biomed Res, Christopher Ingold Bldg,20 Univ London Univ Coll Christopher Ingold Bldg,20 Gordon St London England WC1H 0AJ
Citazione:
G. Wishart et al., "Molecular modelling of the 5-hydroxytryptamine receptors", RECEPT CHAN, 6(4), 1999, pp. 317-335

Abstract

Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such modelsin the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin alpha-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:37:39