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Titolo:
Estrogen receptor-beta: Implications for the prostate gland
Autore:
Chang, WY; Prins, GS;
Indirizzi:
Univ Illinois, Coll Med, Dept Urol, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 Med, Dept Urol, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Physiol & Biophys, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 ysiol & Biophys, Chicago, IL 60612 USA
Titolo Testata:
PROSTATE
fascicolo: 2, volume: 40, anno: 1999,
pagine: 115 - 124
SICI:
0270-4137(19990701)40:2<115:ERIFTP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; HUMAN PITUITARY-TUMORS; LIGAND-BINDING DOMAIN; ALPHA ER-ALPHA; RAT PROSTATE; ADULT-RAT; CHROMOSOMAL LOCALIZATION; DIFFERENTIAL EXPRESSION; REPRODUCTIVE-TRACT; REGIONAL VARIATION;
Keywords:
prostate; estrogen receptor beta; estrogen receptors; estrogens;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Prins, GS Univ2Illinois, Coll Med, Dept Urol, M-C 955,820 S Wood St, Chicago, IL 6061 Univ Illinois M-C 955,820 S Wood St Chicago IL USA 60612 IL 6061
Citazione:
W.Y. Chang e G.S. Prins, "Estrogen receptor-beta: Implications for the prostate gland", PROSTATE, 40(2), 1999, pp. 115-124

Abstract

Estrogens can have profound effects on prostate growth and differentiation. These effects were thought to be mediated by the classical estrogen receptor; however, the discovery of a second estrogen receptor has redefined theestrogen signaling pathway and may have broad implications on estrogen-responsive tissues, including the prostate. The new estrogen receptor, named estrogen receptor-beta (ER beta), is preferentially expressed in the prostate and maintains some characteristics that are different from ER alpha. Establishing the distribution and function of ER beta in the various estrogen-responsive tissues is critical to defining its pharmacological and physiological impact. Differential expression of ER beta may facilitate development of tissue-specific estrogen agonists and antagonists, a goal in the treatment of diseases in estrogen-sensitive tissues such as breast cancer. This article reviews the current knowledge on ER beta and its potential impact on the prostate. Prostate 40:115-124, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:36:49