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Titolo:
Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
Autore:
Gautreau, A; Poullet, PR; Louvard, D; Arpin, M;
Indirizzi:
CNRS,48ab Morphogenese & Signalisat Cellulaires, UMR 144, Inst Curie, F-752 CNRS Paris France 05 Signalisat Cellulaires, UMR 144, Inst Curie, F-752
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 13, volume: 96, anno: 1999,
pagine: 7300 - 7305
SICI:
0027-8424(19990622)96:13<7300:EAPMLS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EZRIN/RADIXIN/MOESIN ERM PROTEINS; PHOSPHOINOSITIDE 3-OH KINASE; MAMMARY EPITHELIAL-CELLS; MICROVILLAR CORE PROTEIN; EPIDERMAL GROWTH-FACTOR; AMINO-TERMINAL DOMAIN; ACTIN-BINDING-SITE; EXTRACELLULAR-MATRIX; CYTOPLASMIC DOMAIN; FAMILY MEMBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Arpin, M CNRS,eLab Morphogenese & Signalisat Cellulaires, UMR 144, Inst Curie, 26 Ru CNRS 26 Rue Ulm Paris France 05 ires, UMR 144, Inst Curie, 26 Ru
Citazione:
A. Gautreau et al., "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway", P NAS US, 96(13), 1999, pp. 7300-7305

Abstract

ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains ofthe plasma membrane, We hare investigated ezrin function in tubulogenesis of a kidney-derived epithelial cell line, LLC-PK1, Here we show that cells overproducing a mutant form of ezrin in which Tyr-353 was changed to a phenylalanine (Y353F) undergo apoptosis when assayed for tubulogenesis. while investigating the mechanism responsible for this apoptosis we found that ezrin interacts with p85, the regulatory subunit of phosphatidylinositol 3-kinase (PI 3 kinase), Two distinct sites of ezrin are involved in this interaction, the amino-terminal domain containing the first 309 aa and the phosphorylated Tyr-353 residue which binds to the carboxyl terminal SH2; domain ofp85. Cells producing Y353F: ezrin are defective in activation of the protein kinase Akt! a downstream target of PI 3-kinase that protects cells against apoptosis, Furthermore, the apoptotic phenotype of these cells is rescued by production of a constitutively activated form of PI 3-kinase, Taken together, these results establish a novel function for ezrin in determining survival of epithelial cells by activating the PI 3-kinase/Akt pathway.

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Documento generato il 30/05/20 alle ore 15:06:18