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Titolo:
Prescribed daily doses and 'risk factors' associated with the use of benzodiazepines in primary care
Autore:
de Las Cuevas, C; Sanz, E; de la Fuente, JA; Cabrera, C; Mateos, A;
Indirizzi:
UnivnLa Laguna, Dept Psychiat, Santa Cruz de Tenerife, Islas Canarias, Spai Univ La Laguna Santa Cruz de Tenerife Islas Canarias Spain anarias, Spai Univina Laguna, Dept Pharmacol, Santa Cruz de Tenerife, Islas Canarias, Spa Univ La Laguna Santa Cruz de Tenerife Islas Canarias Spain Canarias, Spa Canaryias, Hlth Serv, Mental Hlth Serv, Santa Cruz de Tenerife, Islas Canar Canary Isl Hlth Serv Santa Cruz de Tenerife Islas Canarias Spain s Canar
Titolo Testata:
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
fascicolo: 3, volume: 8, anno: 1999,
pagine: 207 - 216
SICI:
1053-8569(199905/06)8:3<207:PDDA'F>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR AFFECTIVE-DISORDER; COMMUNITY; DEPENDENCE; PATTERNS;
Keywords:
anti-anxiety agents; benzodiazepine; medical audit; drug utilization; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: de Las Cuevas, C Santiago Sabina 5-3, Santa Cruz de Tenerife 38007, Islas Canarias, Spain Santiago Sabina 5-3 Santa Cruz de Tenerife Islas Canarias Spain 38007
Citazione:
C. de Las Cuevas et al., "Prescribed daily doses and 'risk factors' associated with the use of benzodiazepines in primary care", PHARMA D S, 8(3), 1999, pp. 207-216

Abstract

Objective - To assess the extent, characteristics and determinants of benzodiazepine prescription in outpatient Primary Health Care. Methods - A clinical audit of a stratified random sample of Primary HealthCare Centres in the seven islands and 1.6 million inhabitants region of 'Canarias' in Spain was carried out. From those centres, a random sample of 1045 clinical records was reviewed and information on diagnosis, prescription and prescribed dosages was collected in a structured questionnaire. A multivariate logistic regression analysis was performed in order to determine the 'risk: factors' for the use of benzodiazepines. Results - Benzodiazepine prescription was recorded in 23.4% of all clinical records; 87.7% of these were for benzodiazepines classified as anxiolytics (N05B) and 12.3% for hypnotics (N05C2). Benzodiazepine prescription was more common for women, elderly, widowed, divorced, low educational background, housewives and retired people. Using multivariate logistic regression, the probability of benzodiazepine prescription was found to be closely related to age, gender and employment status, but not with educational level. Prescribed Daily Doses were lower than Defined Daily Doses (DDD) in 77.1% of all anxiolytic prescriptions, but were in agreement with DDD in 90% of hypnotic prescriptions. The duration of treatment recorded in the clinical records was 25 +/- 21 months, with a range of 1 and 144 months. General Practitioners were responsible for 67% of all benzodiazepine prescription. Anxiolytics were prescribed as a single daily dose in 57% of the cases, and only 'at supper' in 48.6%. Conclusion - Tn the general population attending Primary Health Care Centres of the Canary Islands Health System the prescription of benzodiazepines is higher for women and the elderly, and the most common use is chronic, with a duration of over 2 years in most cases. Anxiolytics are prescribed in doses which are much lower than those used as DDD and were used only 'at night' in almost half of the cases. This could represent an overlapping of the indications with hypnotics, and explain part of the huge difference in the use of anxiolytics in Spain compared with other figures in Europe. This fact must also be taken into account when making inferences of benzodiazepine use from sales statistics, which are very imprecise measures of drug use. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:17:11