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Titolo:
AIDS with inaugural Pneumocystis carinii pneumonia. The impact of triple combination therapy.
Autore:
Yousfi, M; Boibieux, A; Bouhour, D; Biron, F; Chidiac, C; Peyramond, D;
Indirizzi:
Hop Boufarik, Serv Malad Infect, Wilaya de Blida, Algeria Hop Boufarik Wilaya de Blida Algeria d Infect, Wilaya de Blida, Algeria Hop Croix Rousse, Serv Malad Infect & Trop, F-69317 Lyon 04, France Hop Croix Rousse Lyon France 04 d Infect & Trop, F-69317 Lyon 04, France
Titolo Testata:
PATHOLOGIE BIOLOGIE
fascicolo: 5, volume: 47, anno: 1999,
pagine: 566 - 569
SICI:
0369-8114(199905)47:5<566:AWIPCP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
FRE
Keywords:
first AIDS-defining events; inaugural Pneumocystis carinii pneumonia; antiretroviral triple combination therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
0
Recensione:
Indirizzi per estratti:
Indirizzo: Yousfi, M Hop Boufarik, Serv Malad Infect, Wilaya de Blida, Algeria Hop Boufarik Wilaya de Blida Algeria Wilaya de Blida, Algeria
Citazione:
M. Yousfi et al., "AIDS with inaugural Pneumocystis carinii pneumonia. The impact of triple combination therapy.", PATH BIOL, 47(5), 1999, pp. 566-569

Abstract

To evaluate the impact of the advent of triple combination therapy for AIDS on the nature of the first AIDS-definiting event, a retrospective study was conducted in the infectious diseases department of the Croix-Rousse Teaching Hospital in Lyon, France. The 280 patients entered in the AIDS registry of the department between January 1, 1994, and August 31, 1998, were studied. In 1994 and 1995, 33.05% of registry entries were for a first AIDS-defining event. After the introduction of triple combination therapy during the second half of 1996, this proportion increased significantly from 30.1% for the period between January 1, 1994, and June 30, 1996, to 56.7% for the period from July 1, 1996, to August 31, 1998 (P=0.00003), The proportion ofPneumocystis carinii pneumonia (PCP) occuring as the first AIDS-defining event also rose significantly between these two periods, from 47.5% to 82.1%(P=0.002). These data indicate that triple combination therapy may be associated with an increase in the proportion of first AIDS-defining events, most notably of inaugural PCP. National data support this possibility. It would be of interest to conduct early screening campaigns for AIDS in order toallow early effective therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:42:47