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Titolo:
Emerging insights into the genesis of epilepsy
Autore:
McNamara, JO;
Indirizzi:
Vet Affairs Med Ctr, Durham, NC 27710 USA Vet Affairs Med Ctr Durham NC USA 27710 irs Med Ctr, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Med Neurol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Dept Med Neurol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
NATURE
fascicolo: 6738, volume: 399, anno: 1999, supplemento:, S
pagine: A15 - A22
SICI:
0028-0836(19990624)399:6738<A15:EIITGO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE EPILEPSY; POTASSIUM CHANNEL GENE; FAMILIAL NEONATAL CONVULSIONS; GRANULE CELL NEUROGENESIS; GLUTAMATE-RECEPTOR GLUR3; KAINATE-TREATED RATS; HUMAN TEMPORAL-LOBE; DENTATE GYRUS; RASMUSSENS ENCEPHALITIS; LIMBIC SEIZURES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: McNamara, JO VetSAffairs Med Ctr, 401 Bryan Res Bldg,Res Dr,Box 3676, Durham, NC 27710 U Vet Affairs Med Ctr 401 Bryan Res Bldg,Res Dr,Box 3676 Durham NC USA 27710
Citazione:
J.O. McNamara, "Emerging insights into the genesis of epilepsy", NATURE, 399(6738), 1999, pp. A15-A22

Abstract

Epilepsies are a diverse collection of brain disorders that affect 1-2% ofthe population. Current therapies are unsatisfactory as they provide only symptomatic relief, are effective fin only a subset of affected individuals, and are often accompanied by persistent toxic effects. It is hoped that Insight into the cellular and molecular mechanisms of epileptogenesis will lead to new therapies, prevention, or even a cure. Emerging Insights point to alterations of synaptic function and intrinsic properties of neurons as common mechanisms underlying the hyperexcitability In diverse forms of epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:52:21