Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Probucol suppresses ICAM-1 expression in rat mesangial cells: Possible role of IL-1
Autore:
Sugiura, T; Wada, A; Moriyama, T; Horio, M; Ueda, N; Imai, E; Hori, M;
Indirizzi:
Osaka Univ, Sch Med, Osaka Natl Hosp, Dept Med 1, Osaka, Japan Osaka UnivOsaka Japan h Med, Osaka Natl Hosp, Dept Med 1, Osaka, Japan Osaka Univ, Sch Med, Dept Clin Lab Sci, Osaka, Japan Osaka Univ Osaka Japan a Univ, Sch Med, Dept Clin Lab Sci, Osaka, Japan Nara Inst Sci & Technol, Nara 63001, Japan Nara Inst Sci & Technol Nara Japan 63001 ci & Technol, Nara 63001, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
, volume: 56, anno: 1999, supplemento:, 71
pagine: S167 - S170
SICI:
0085-2538(199907)56:<S167:PSIEIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR ANTAGONIST; ADHESION MOLECULE-1 EXPRESSION; GLOMERULONEPHRITIS; INHIBITION;
Keywords:
glomerulonephritis; intercellular adhesion molecule-1; interleukin-1; progressive renal disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Sugiura, T Osaka Univ, Sch Med, Dept Med 1, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
T. Sugiura et al., "Probucol suppresses ICAM-1 expression in rat mesangial cells: Possible role of IL-1", KIDNEY INT, 56, 1999, pp. S167-S170

Abstract

Interleukin-1 (IL-1) participates in the progression of glomerulonephritisby up-regulating intercellular adhesion molecule-1 (ICAM-1) expression in experimental glomerulonephritis. Probucol, an anti-hyperlipidemic agent, ameliorates some types of glomerulonephritis regardless of serum cholesterol levels, and is also reported to inhibit IL-1 release from macrophages in atherosclerotic lesions. However, little is known about the mechanism of thisfavorable action on glomerular injury. We examined whether or not probucolinhibits ICAM-1 expression by suppression of IL-1 action in cultured rat mesangial cells. In this brief report, we review the actions of probucol on IL-1 secretion and discuss the possible mechanism by which probucol may suppress the glomerular injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:12:08