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Titolo:
Chemoembolization of hepatocellular carcinoma with cisplatin, doxorubicin,mitomycin-C, ethiodol and polyvinyl alcohol: Prospective evaluation of response and survival in a US population
Autore:
Solomon, B; Soulen, MC; Baum, RA; Haskal, ZJ; Shlansky-Goldberg, RD; Cope, C;
Indirizzi:
Univ Penn, Div Intervent Radiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 nt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 6, volume: 10, anno: 1999,
pagine: 793 - 798
SICI:
1051-0443(199906)10:6<793:COHCWC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; HEPATIC-ARTERY; OILY CHEMOEMBOLIZATION; IODIZED OIL; EMBOLIZATION; LIVER; PROGNOSIS; CANCER; MANAGEMENT; LIPIODOL;
Keywords:
hepatic artery, chemotherapeutic infusion; liver neoplasms, chemotherapeutic infusion; liver neoplasms, therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Soulen, MC Univ Penn, Div Intervent Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3400 Spruce St Philadelphia PA USA 19104 PA 19104 USA
Citazione:
B. Solomon et al., "Chemoembolization of hepatocellular carcinoma with cisplatin, doxorubicin,mitomycin-C, ethiodol and polyvinyl alcohol: Prospective evaluation of response and survival in a US population", J VAS INT R, 10(6), 1999, pp. 793-798

Abstract

PURPOSE: To evaluate response and survival after hepatic chemoembolizationwith cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol in a U.S. population of patients with hepatocellular carcinoma,MATERIALS AND METHODS: Thirty-eight consecutive patients were treated: 35%stage I, 62% stage II, 3% stage III, Fifty-one percent had cirrhosis, Chemoembolization was performed at approximately monthly intervals for one to seven sessions (mean, 2.2), Pretreatment and posttreatment cross-sectional imaging and alphafetoprotein (AFP) levels were obtained prospectively 1 month after treatment and then every 3 months. Thirty-day response was calculated by means of the the World Health Organization/Eastern Cooperative Oncology Group criteria. RESULTS: One patient was lost to follow-up. In seven patients, lesions became resectable after chemoembolization. Among 13 evaluable patients with initially elevated AFP level, 70% had a partial biologic response (>50% decrease in AFP), 15% had a minor response (25-50% decrease), and the remaining 15% remained stable. Among 25 patients evaluable for morphologic response, 36% had a partial response, 32% had a minor response, and 32% remained stable, No patients had progression of disease while receiving therapy, The cumulative survival was 60% at 1 year, 41% at 2 years, and 16% at 3 years. Twopatients developed progressive hepatic failure, Thirty-day mortality was 3% (one patient). CONCLUSION: These results compare favorably to published response and survival data for chemoembolization of advanced hepatocellular carcinoma fr om Asia and Europe.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 13:05:04