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Titolo:
Evaluation of a modified arrow-trerotola percutaneous thrombolytic device for treatment of acute pulmonary embolus in a canine model
Autore:
Brown, DB; Cardella, JF; Wilson, RP; Singh, H; Waybill, PN;
Indirizzi:
Penn State Univ Hosp, Dept Radiol, Hershey, PA 17033 USA Penn State Univ Hosp Hershey PA USA 17033 t Radiol, Hershey, PA 17033 USA Penn State Univ Hosp, Dept Comparat Med, Hershey, PA 17033 USA Penn State Univ Hosp Hershey PA USA 17033 arat Med, Hershey, PA 17033 USA SUNY Syracuse, Hlth Sci Ctr, Dept Radiol, Syracuse, NY 13210 USA SUNY Syracuse Syracuse NY USA 13210 , Dept Radiol, Syracuse, NY 13210 USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 6, volume: 10, anno: 1999,
pagine: 733 - 740
SICI:
1051-0443(199906)10:6<733:EOAMAP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPLATZ THROMBECTOMY DEVICE; MECHANICAL THROMBECTOMY; PULSE-SPRAY; FRAGMENTATION; CATHETER; THROMBOSIS;
Keywords:
embolism, pulmonary; thrombectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DB PennPAtate Univ Hosp, Dept Radiol, Room HG 315C,H066,500 Univ Dr, Hershey, Penn State Univ Hosp Room HG 315C,H066,500 Univ Dr Hershey PA USA 17033
Citazione:
D.B. Brown et al., "Evaluation of a modified arrow-trerotola percutaneous thrombolytic device for treatment of acute pulmonary embolus in a canine model", J VAS INT R, 10(6), 1999, pp. 733-740

Abstract

PURPOSE: Massive pulmonary embolus (PE) is often rapidly fatal. Surgical thrombectomy has a mortality rate as high as 74%. Multiple percutaneous methods have been tested with limited success. The purpose of this study was toevaluate the Arrow-Trerotola percutaneous thrombolytic device (PTD) for (i) the ability to clear pulmonary embolus and (ii) the effect on normal pulmonary vasculature, These were tested in a canine model,MATERIALS AND METHODS: Iatrogenic unilateral massive PEs were created in nine canines, These PEs were then treated with the PTD, The device was also activated in the normal pulmonary artery. Immediately after treatment, six animals were killed. Three animals were allowed to recover and underwent pulmonary arteriography 1 month later to evaluate pulmonary hypertension, stenosis, or occlusion; they were then killed, Autopsy specimens were evaluated for histologic evidence of acute or chronic vascular injury. RESULTS: Acutely, the PTD effectively thrombolysed the PE in all animals. Histologically, there was moderate intimal injury, but no evidence of pulmonary artery disruption. There was one device failure. One month after treatment, there was no radiographic evidence of pulmonary stenosis at device activation sites, no pulmonary hypertension, and only mild histologic evidence of scar formation,CONCLUSION: In preliminary animal testing, the PTD is safe and effective for treating large central pulmonary emboli, Human clinical trials are warranted.

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Documento generato il 01/12/20 alle ore 08:10:39