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Titolo:
R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients
Autore:
Muller, T; Baum, SS; Haussermann, P; Przuntek, H; Rommelspacher, H; Kuhn, W;
Indirizzi:
Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 pt Neurol, D-4630 Bochum, Germany Freen,niv Berlin, Benjamin Franklin Hosp, Dept Clin Neurobiol, D-1000 Berli Free Univ Berlin Berlin Germany D-1000 Dept Clin Neurobiol, D-1000 Berli
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 164, anno: 1999,
pagine: 158 - 162
SICI:
0022-510X(19990401)164:2<158:RASANI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLTRANSFERASE ACTIVITY; DOPAMINERGIC NEUROTOXIN; LIQUID-CHROMATOGRAPHY; N-METHYL(R)SALSOLINOL; ALCOHOLICS; BRAIN; DISEASE; PLASMA; ION; 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE;
Keywords:
salsolinol; enantiomers; cerebrospinal fluid; Parkinson's disease; N-methylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, T Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 D-4630 Bochum, Germany
Citazione:
T. Muller et al., "R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients", J NEUR SCI, 164(2), 1999, pp. 158-162

Abstract

Various investigators address an augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL), or an increased N-methylation of these compounds as putative pathophysiologic mechanisms in Parkinson's disease (PD). Objectives of this study were (1) the evaluation of a putative elevation of enantiomers (R-, S-) of SAL and (2) the investigation of relations between these metabolic precursors of neurotoxic N-methylated-SAL (NMSAL) and dopamine in cerebrospinal fluid of untreated de-novo Parkinsonian patients andage- and sex-matched healthy controls. Levels of R- and S-SAL and dopaminedid not significantly (R-SAL: P=0.75, S-SAL: P=0.69, dopamine: P=0.46) differ and dopamine did not correlate to R-SAL and S-SAL in both groups. We conclude, that central accumulation of R-NMSAL, which is neurotoxic to dopaminergic nigrostriatal neurons, is not due to elevated synthesis of R-SAL and/or S-SAL in PD. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:41:09