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Titolo:
Assessment of regional and global left ventricular function by reinjectionTl-201 and rest Tc-99m sestamibi ECG-gated SPECT - Comparison with three-dimensional magnetic resonance imaging
Autore:
Tadamura, E; Kudoh, T; Motooka, M; Inubushi, M; Shirakawa, S; Hattori, N; Okada, T; Matsuda, T; Koshiji, T; Nishimura, K; Matsuda, K; Konishi, J;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, Kyoto Kyoto Univ Kyoto Japan 6068507 l Med & Diagnost Imaging, Sakyo Ku, Kyoto Kyoto Univ, Grad Sch Med, Dept Internal Med, Div 3, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Internal Med, Div 3, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Med Informat, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 , Dept Med Informat, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Cardiovasc Surg, Kyoto 6068507, Japan KyotoUniv Kyoto Japan 6068507 ept Cardiovasc Surg, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 4, volume: 33, anno: 1999,
pagine: 991 - 997
SICI:
0735-1097(19990315)33:4<991:AORAGL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; TRANSIENT ISCHEMIC DILATION; MYOCARDIAL PERFUSION SPECT; EJECTION FRACTION; VIABLE MYOCARDIUM; WALL-MOTION; SCINTIGRAPHY; QUANTIFICATION; IDENTIFICATION; TETROFOSMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tadamura, E Kyotoogoin, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, 54 Sh Kyoto Univ 54 Shogoin Kyoto Japan 6068507 ng, Sakyo Ku, 54 Sh
Citazione:
E. Tadamura et al., "Assessment of regional and global left ventricular function by reinjectionTl-201 and rest Tc-99m sestamibi ECG-gated SPECT - Comparison with three-dimensional magnetic resonance imaging", J AM COL C, 33(4), 1999, pp. 991-997

Abstract

OBJECTIVES The purpose of this study was to test the ability of reinjection thalium-201 and rest technetium-99m sestamibi ECG (electrocardiopraphic)-gated SPECT (i.e., reinjection-g-SPECT [single-photon emission computed tomography] and MIBI-g-SPECT) to determine regional and global functional parameters. BACKGROUND The EGG-gated perfusion SPECT was reported to provide accurate left ventricular ejection fraction (LVEF) using an automated algorithm. We hypothesized that other various functional data may be obtained using reinjection-g SPECT and MIBI-g-SPECT. METHODS Reinjection-g-SPECT, MIBI-g SPECT, and three-dimensional magnetic resonance imaging (3DMRI) were conducted in 20 patients with coronary artery disease. Regional wall motion (RWM) and wall thickening (RWT) were analyzed using semiquantitative visual scoring by each g-SPECT and 3DMRI. The left ventricular end-systolic and end-diastolic volumes (EDV, ESV) and LVEF estimated by reinjection and MIBI-g-SPECT were compared with the results of 3DMRI. RESULTS A high degree of agreement in RWM and RWT assessment was observed between each g-SPECT and 3DMRI (kappa >.70, p < .001). The LVEF values by reinjection- and MIBI-g-SPECT correlated and agreed well with those by 3DMRI(reinjection: r =.92, SEE = 5.9%, SD of differences = 5.7%; sestamibi: r =.94, SEE = 4.4%, SD of differences = 5.1%). The same also pertained to EDV(reinjection: r = .85, SEE = 18.7 ml, SD of differences = 18.4 mi; sestamibi: r =.92, SEE = 13.1 ml, SD of differences = 13.0 mi) and ESV (reinjection: r = .94, SEE = 10.3 mi, SD of differences = 10.3 ml; sestamibi: r = .97,SEE = 6.7 ml [p < .05 vs. reinjection by F test], SD of differences = 6.6 mi [p < .05 vs. reinjection by F test]). CONCLUSIONS Reinjection- and MIBI-g-SPECT provide clinically satisfactory various functional data. These functional date in combination with the perfusion information will improve diagnostic and prognostic accuracy without an increase in cost or the radiation dose to the patients. (J Am Cell Cardiol 1999;33:991-7) (C) 1999 by the American College of Cardiology.

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Documento generato il 03/06/20 alle ore 09:18:11