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Titolo:
Serotonergic modulation of synapses in the developing gerbil lateral superior olive
Autore:
Fitzgerald, KK; Sanes, DH;
Indirizzi:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Dept Biophys, New York, NY 10003 USA NYU New York NY USA 10003NYU, Dept Biophys, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 6, volume: 81, anno: 1999,
pagine: 2743 - 2752
SICI:
0022-3077(199906)81:6<2743:SMOSIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED CATION CURRENT; CENTRAL AUDITORY-SYSTEM; DORSAL RAPHE NEURONS; COCHLEAR NUCLEUS; TRAPEZOID BODY; GLYCINERGIC TRANSMISSION; MEDIAL NUCLEUS; BRAIN-STEM; DEVELOPMENTAL-CHANGES; DENDRITIC ARBORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Sanes, DH NYU, Ctr Neural Sci, 4 Washington Pl,Room 809, New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
K.K. Fitzgerald e D.H. Sanes, "Serotonergic modulation of synapses in the developing gerbil lateral superior olive", J NEUROPHYS, 81(6), 1999, pp. 2743-2752

Abstract

Serotonergic modulation of synapses in the developing gerbil lateral superior olive. J. Neurophysiol. 81: 2743-2752, 1999. The lateral superior olive(LSO) is a primary site of binaural convergence that responds selectively to changes in interaural level difference (ILD) by integrating ipsilateral excitatory and contralateral inhibitory inputs. The circuit matures during the first three postnatal weeks, undergoing several structural and functional changes that are influenced by afferent activity. Therefore modulation of synaptic activity by neuromodulators may participate in the maturation ofthis circuit. The present study describes robust effects of serotonin (5-MT) on LSO synaptic function. Using whole cell voltage-clamp recording from gerbil LSO neurons (postnatal days 6-13) in an in vitro slice preparation, we have identified several distinct forms of serotonergic modulation of spontaneous and evoked synaptic transmission. First, 1-2 min application of 5-HT (100 mu M) activated prolonged bursts of spontaneous inhibitory postsynaptic currents (IPSCs). However, there was an age-dependent decline, such that this effect rarely was observed beyond postnatal day 8. 5-HT apparently increased the excitability of inhibitory afferents, because 5-HT-induced IPSCs were blocked by tetrodotoxin. A second effect of 5-HT was to depress rapidly and profoundly the amplitude of electrically evoked excitatory postsynaptic currents (EPSCs). In contrast, 5-HT also depressed evoked IPSCs but to a significantly lesser degree. The receptor subtypes mediating these effects were examined using specific 5-HT agonists and antagonists. A 5-MT, agonist, 5-carbox-amidotryptamine, produced EPSC depression but did not induce spontaneous IPSCs. A 5-HT, agonist, alpha-Me-5-HT, reproduced all the observed effects of 5-HT (PSC depression as well as induction of spontaneous IPSCs), whereas a 5-HT, antagonist, ketanserin, blocked the induction of spontaneous IPSCs. Therefore induction of spontaneous IPSCs is mediated by 5-MT, receptors, whereas both 5-MT, and 5-MT, receptor types contribute to PSCdepression. Serotonergic modulation of LSO synapses may have consequences for both developmental plasticity and auditory function. Serotonergic induction of IPSCs was observed primarily in young animals and thus may represent a mechanism for amplifying the activity of inhibitory synapses in LSO during a period of use-dependent plasticity in postnatal development. PSC depression, which preferentially affects excitation, is a potential mechanism for modulation of ILD tuning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:08:14