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Titolo:
Evidence for cortical dysfunction in clinically non-demented patients withParkinson's disease: a proton MR spectroscopy study
Autore:
Hu, MTM; Taylor-Robinson, SD; Chaudhuri, KR; Bell, JD; Morris, RG; Clough, C; Brooks, DJ; Turjanski, N;
Indirizzi:
HammersmithN,osp, Imperial Coll, Sch Med, MRC,Cyclotron Unit, London W12 0N Hammersmith Hosp London England W12 0NN RC,Cyclotron Unit, London W12 0N Hammersmith2Hosp, Imperial Coll, Sch Med, Robert Steiner MR Unit, London W1 Hammersmith Hosp London England W12 0NN obert Steiner MR Unit, London W1 Kings Coll Hosp, Sch Med, London SE5 8AF, England Kings Coll Hosp LondonEngland SE5 8AF Sch Med, London SE5 8AF, England Inst Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 1, volume: 67, anno: 1999,
pagine: 20 - 26
SICI:
0022-3050(199907)67:1<20:EFCDIC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; PROGRESSIVE SUPRANUCLEAR PALSY; MINI-MENTAL STATE; IN-VIVO; ALZHEIMERS-DISEASE; HUMAN-BRAIN; MULTIPLE-SCLEROSIS; N-ACETYLASPARTATE; NORMATIVE DATA; DIAGNOSIS;
Keywords:
Parkinson's disease; magnetic resonance; spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, MTM Hammersmithondon, Imperial Coll, Sch Med, MRC,Cyclotron Unit, Du Cane Rd, L Hammersmith Hosp Du Cane Rd London England W12 0NN Du Cane Rd, L
Citazione:
M.T.M. Hu et al., "Evidence for cortical dysfunction in clinically non-demented patients withParkinson's disease: a proton MR spectroscopy study", J NE NE PSY, 67(1), 1999, pp. 20-26

Abstract

Objectives-To investigate whether proton magnetic resonance spectroscopy (H-1 MRS) can detect cortical dysfunction in non-demented patients with Parkinson's disease, and to correlate changes with cognitive function on formalneuropsychological testing. Methods-Multivoxel H-1 MRS was performed in 17 patients with levodopa treated idiopathic Parkinson's disease without clinical dementia, and 10 age matched control subjects. Measurements of N-acetylaspartate (NAA)/choline (Cho), NAA/cresttine+phosphocreatine (Cr), and Cho/Cr were obtained from rightand left temporoparietal cortex and occipital cortex. Fourteen patients with Parkinson's disease underwent a full battery of neuropsychological testing including performance and verbal subtests of the WAIS-R, Boston naming test, FAS test, and California verbal learning test. Results-There were significant temporoparietal cortex reductions in NAA/Crratios in right and left averaged spectra of the patients with Parkinson'sdisease (p=0.012 after Bonferroni correction) and in spectra contralateralto the worst clinically affected limbs of the patients with Parkinson's disease compared with controls (p = 0.003 after Bonferroni correction). Therewas a significant correlation between reduction in NAA/Cr ratios and measures of global cognitive decline, occurring independently of motor impairment (p=0.019). Conclusions-This study suggests that H-1 MRS can detect temporoparietal cortical dysfunction in non-demented patients with Parkinson's disease. Further longitudinal studies are needed to investigate whether these H-1 MRS changes are predictive of future cognitive impairment in the subset of patients with Parkinson's disease who go on to develop dementia, or occur as part of the normal Parkinson's disease process.

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Documento generato il 13/07/20 alle ore 04:53:42