Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Type 1 inositol 1,4,5-trisphosphate receptor knock-out mice: their phenotypes and their meaning in neuroscience and clinical practice
Autore:
Matsumoto, M; Nagata, E;
Indirizzi:
Univ Tokyo, Inst Phys & Chem Res, Brain Sci Inst, Minato Ku, Tokyo, Japan Univ Tokyo Tokyo Japan hem Res, Brain Sci Inst, Minato Ku, Tokyo, Japan Univ Tokyo, Inst Med Sci, Dept Mol Neurobiol, Minato Ku, Tokyo, Japan UnivTokyo Tokyo Japan Sci, Dept Mol Neurobiol, Minato Ku, Tokyo, Japan Keio Univ, Dept Neurol, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Dept Neurol, Tokyo, Japan
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 5, volume: 77, anno: 1999,
pagine: 406 - 411
SICI:
0946-2716(199905)77:5<406:T1I1RK>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; MUTANT MICE; EPILEPTIFORM ACTIVITY; MOTOR COORDINATION; CALCIUM CURRENTS; ACTIVATION; EXPRESSION; INDUCTION; EPILEPSY; SEIZURES;
Keywords:
inositol 1,4,5-trisphosphate receptor; calcium release from intracellular stores; gene targeting; ataxia; epileptic seizures;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, M Univedai,o, Inst Phys & Chem Res, Brain Sci Inst, Minato Ku, 4-6-1 Shirokan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan u, 4-6-1 Shirokan
Citazione:
M. Matsumoto e E. Nagata, "Type 1 inositol 1,4,5-trisphosphate receptor knock-out mice: their phenotypes and their meaning in neuroscience and clinical practice", J MOL MED-J, 77(5), 1999, pp. 406-411

Abstract

Cytoplasmic calcium, which acts as a second messenger, is derived not onlyfrom outside the cell but also from intracellular stores. A receptor for inositol 1,4,5-trisphosphate (IP3), an intracellular second messenger, is located on these internal calcium stores and functions as a calcium releasingchannel. The "type 1" IP3 receptor (IP(3)R1) is concentrated predominantlyin cerebellar Purkinje cells and is also widely present in other neural and peripheral tissues, but many of its physiological roles in these cells are still unclear. We have previously succeeded in obtaining mice with disruption of this IP(3)R1 gene, in which brain IP3-induced calcium release was almost completely abolished. They were rarely born alive, indicating that IP(3)R1 has some functions during embryonic development. Animals exhibited severe neurological symptoms, ataxia and epilepsy, and were shown to be deficient in the cerebellar long-term depression. They give us promising clues regarding the physiological roles of calcium release from internal stores and serve as a model for the relevant human disease states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:38:35