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Titolo:
Cholestasis of pregnancy
Autore:
McDonald, JA;
Indirizzi:
Wollongong Hosp, Dept Gastroenterol, Wollongong, NSW 2500, Australia Wollongong Hosp Wollongong NSW Australia 2500 ongong, NSW 2500, Australia
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 6, volume: 14, anno: 1999,
pagine: 515 - 518
SICI:
0815-9319(199906)14:6<515:COP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC ACID THERAPY; INTRA-HEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS; BILE-ACIDS; DOUBLE-BLIND; LIVER; DEXAMETHASONE; PREVALENCE; PLACEBO; CHILE;
Keywords:
bile acids; foetal distress; pregnancy; pruritus; ursodeoxycholic acid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: McDonald, JA Wollongongliasp, Dept Gastroenterol, POB 1798, Wollongong, NSW 2500, Austra Wollongong Hosp POB 1798 Wollongong NSW Australia 2500 Austra
Citazione:
J.A. McDonald, "Cholestasis of pregnancy", J GASTR HEP, 14(6), 1999, pp. 515-518

Abstract

Cholestasis of pregnancy is the commonest liver disease unique to pregnancy and is characterized by pruritus in the mother in late pregnancy, withoutany skin rashes. This is accompanied by an elevation of the serum bile acids. Liver function test abnormalities may occur. Abdominal pain is not a feature and liver failure does not occur. The diagnosis is made by a suggestive history and exclusion of other causes by the history, serology and an upper abdominal ultrasound. All symptoms and signs should disappear within 4 weeks post-partum; prolonged post-partum courses should prompt a search forother causes, such as primary biliary cirrhosis. The syndrome is associated with a five-fold increased incidence of stillbirth, intra-partum foetal distress and pre-term labour. The reason is not clear and not predictable. The accepted management is induction or delivery at 38 weeks, which has led to a reduction in poor foetal outcome. Preliminary studies using ursodeoxycholic acid show symptomatic and biochemical improvement in most women treated. There is also a suggestion of an improved foetal outcome and treatment should be considered in women who present with the condition earlier in pregnancy. (C) 1999 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:19:32